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PMID: 15322271 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Drosophila lifespan enhancement by exogenous bacteria.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 35 ·2004-08-31 ·Pages 12974-9

Brummel T, Ching A, Seroude L, Simon AF, Benzer S

Abstract

We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria and longevity-enhancing genes.

MeSH Terms
Age Factors Animals Anti-Bacterial Agents/pharmacology Drosophila/drug effects,genetics,microbiology,physiology Germ-Free Life/physiology Longevity/drug effects,physiology
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Brummel Ted
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
Ching Alisa
Seroude Laurent
Simon Anne F
Benzer Seymour
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0405207101
Published
2004-08-31
Epub
2004-00-20
Pages
12974-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC516503
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0405207101 PMC Full Text View journal details
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