Home LiteratureArticle Details
PMID: 15331691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Retroviral capsid determinants of Fv1 NB and NR tropism.

Journal of virology ·Vol. 78 ·No. 18 ·2004-09-00 ·Pages 9592-8

Stevens A, Bock M, Ellis S, LeTissier P, Bishop KN, Yap MW, Taylor W, Stoye JP

Abstract

The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.

MeSH Terms
Alleles Amino Acid Sequence Animals BALB 3T3 Cells Base Sequence Binding Sites Capsid Proteins/chemistry,genetics,physiology Cell Line DNA/genetics DNA, Viral/genetics Genes, Viral Humans Leukemia Virus, Murine/genetics,isolation & purification,pathogenicity Mice Models, Molecular Molecular Sequence Data NIH 3T3 Cells Proteins/genetics,physiology Virulence/genetics
Chemicals
Capsid Proteins DNA, Viral Fv1 protein, mouse Proteins DNA
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Stevens Anthony
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Bock Michael
Ellis Scott
LeTissier Paul
Bishop Kate N
Yap Melvyn W
Taylor Willie
Stoye Jonathan P
References (50)
50 references, click to expand
  1. Multiple sequence threading: an analysis of alignment quality and stability.
    J Mol Biol. 1997 Jun 27;269(5):902-43 PMID: 9223650
  2. A linkage map of endogenous murine leukemia proviruses.
    Genetics. 1990 Feb;124(2):221-36 PMID: 2155154
  3. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.
    J Virol. 1970 Feb;5(2):221-5 PMID: 4317349
  4. Image reconstructions of helical assemblies of the HIV-1 CA protein.
    Nature. 2000 Sep 21;407(6802):409-13 PMID: 11014200
  5. Operating under a Gag order: a block against incoming virus by the Fv1 gene.
    Cell. 1996 Sep 6;86(5):691-3 PMID: 8797814
  6. Nucleotide sequences of gag-pol regions that determine the Fv-1 host range property of BALB/c N-tropic and B-tropic murine leukemia viruses.
    J Virol. 1983 Dec;48(3):779-84 PMID: 6313971
  7. Restriction of lentivirus in monkeys.
    Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11920-5 PMID: 12154231
  8. The PSIPRED protein structure prediction server.
    Bioinformatics. 2000 Apr;16(4):404-5 PMID: 10869041
  9. Six-NB-tropic murine leukemia viruses derived from a B-tropic virus of BALB/c have altered p30.
    J Virol. 1977 Jan;21(1):309-18 PMID: 189069
  10. Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells.
    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1298-303 PMID: 12547912
  11. Positional cloning of the mouse retrovirus restriction gene Fv1.
    Nature. 1996 Aug 29;382(6594):826-9 PMID: 8752279
  12. Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction.
    J Virol. 1985 Aug;55(2):281-5 PMID: 2991555
  13. Physical mapping of the Fv-1 tropism host range determinant of BALB/c murine leukemia viruses.
    J Virol. 1983 Dec;48(3):685-96 PMID: 6313967
  14. Consensus structural models for the amino terminal domain of the retrovirus restriction gene Fv1 and the murine leukaemia virus capsid proteins.
    BMC Struct Biol. 2004 Jan 12;4:1 PMID: 14715087
  15. Crystal structure of dimeric HIV-1 capsid protein.
    Nat Struct Biol. 1996 Sep;3(9):763-70 PMID: 8784350
  16. Restriction of multiple divergent retroviruses by Lv1 and Ref1.
    EMBO J. 2003 Feb 3;22(3):385-94 PMID: 12554640
  17. Genetic assay for multimerization of retroviral gag polyproteins.
    J Virol. 1992 Aug;66(8):5157-60 PMID: 1629970
  18. Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro.
    J Virol. 1992 Oct;66(10):5959-66 PMID: 1326652
  19. Solution structure and dynamics of the Rous sarcoma virus capsid protein and comparison with capsid proteins of other retroviruses.
    J Mol Biol. 2000 Feb 18;296(2):633-49 PMID: 10669613
  20. Nucleotide sequence of AKV murine leukemia virus.
    J Virol. 1984 Feb;49(2):471-8 PMID: 6319746
  21. Determination of the number of nonoverlapping antigenic areas on Hong Kong (H3N2) influenza virus hemagglutinin with monoclonal antibodies and the selection of variants with potential epidemiological significance.
    Virology. 1980 Jul 15;104(1):139-48 PMID: 6156537
  22. Reversal of Fv-1 host range by in vitro restriction endonuclease fragment exchange between molecular clones of N-tropic and B-tropic murine leukemia virus genomes.
    J Virol. 1983 Oct;48(1):110-9 PMID: 6310140
  23. The Fv-1 gene of the mouse and its control of murine leukemia virus replication.
    Curr Top Microbiol Immunol. 1979;86:67-122 PMID: 227645
  24. Phylogenetic relationship of the complete Rauscher murine leukemia virus genome with other murine leukemia virus genomes.
    Virology. 1997 Nov 10;238(1):64-7 PMID: 9375009
  25. RNA sequencing provides evidence for allelism of determinants of the N-, B- or NB-tropism of murine leukemia viruses.
    Cell. 1979 Jan;16(1):43-50 PMID: 217545
  26. Nucleotide sequence of Moloney murine leukaemia virus.
    Nature. 1981 Oct 15-21;293(5833):543-8 PMID: 6169994
  27. How viruses escape from cytotoxic T lymphocytes: molecular parameters and players.
    Virology. 1997 Aug 4;234(2):179-85 PMID: 9268148
  28. T1 oligonucleotide maps of N-, B-, and B leads to NB-tropic murine leukemia viruses derived from BALB/c.
    J Virol. 1978 Apr;26(1):143-52 PMID: 206721
  29. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
    Nat Med. 2003 Sep;9(9):1138-43 PMID: 12897779
  30. One base change is sufficient for host range conversion of murine leukemia virus from B to NB tropism.
    Arch Virol. 1997;142(9):1889-94 PMID: 9672647
  31. Use of a transient assay for studying the genetic determinants of Fv1 restriction.
    J Virol. 2000 Aug;74(16):7422-30 PMID: 10906195
  32. Identification of the regions of Fv1 necessary for murine leukemia virus restriction.
    J Virol. 2001 Jun;75(11):5182-8 PMID: 11333899
  33. Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene.
    J Virol. 1997 Jul;71(7):5652-7 PMID: 9188643
  34. Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26.
    J Mol Biol. 1999 Feb 12;286(1):83-93 PMID: 9931251
  35. Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations.
    J Natl Cancer Inst. 1960 Apr;24:933-51 PMID: 14423465
  36. Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus.
    J Virol. 1980 Jan;33(1):475-86 PMID: 6245244
  37. Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.
    Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11914-9 PMID: 12154227
  38. Structural organization of authentic, mature HIV-1 virions and cores.
    EMBO J. 2003 Apr 1;22(7):1707-15 PMID: 12660176
  39. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice.
    J Natl Cancer Inst. 1970 Jul;45(1):163-9 PMID: 5449211
  40. Single amino acid changes in the murine leukemia virus capsid protein gene define the target of Fv1 resistance.
    Virology. 1996 Nov 15;225(2):300-5 PMID: 8918916
  41. Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
    Cell. 1996 Dec 27;87(7):1285-94 PMID: 8980234
  42. Dynamic sequence databank searching with templates and multiple alignment.
    J Mol Biol. 1998 Jul 17;280(3):375-406 PMID: 9665844
  43. Interactions between host and viral genomes in mouse leukemia.
    Annu Rev Genet. 1977;11:277-96 PMID: 202189
  44. Cloning of the MCF1233 murine leukemia virus and identification of sequences involved in viral tropism, oncogenicity and T cell epitope formation.
    Virus Res. 1994 Dec;34(3):339-49 PMID: 7531924
  45. Production of pigs transgenic for human decay accelerating factor.
    Transplant Proc. 1994 Jun;26(3):1400-1 PMID: 7518134
  46. A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia.
    J Natl Cancer Inst. 1962 Sep;29:515-43 PMID: 14490596
  47. An intracellular block to primate lentivirus replication.
    Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11549-51 PMID: 12195025
  48. Solution structure of the capsid protein from the human T-cell leukemia virus type-I.
    J Mol Biol. 1999 Aug 13;291(2):491-505 PMID: 10438634
  49. A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.
    J Virol. 2000 Jun;74(11):5385-7 PMID: 10799620
  50. Susceptibility to two strains of Friend leukemia virus in mice.
    Science. 1967 Jan 27;155(3761):461-2 PMID: 6015694
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.78.18.9592-9598.2004
Published
2004-09-00
Pages
9592-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC514981
Subset
IM
Databases
GENBANK
AY294332
External Links
PubMed source DOI: 10.1128/JVI.78.18.9592-9598.2004 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2