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PMID: 1549472 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Critical comparison of consensus methods for molecular sequences.

Nucleic acids research ·Vol. 20 ·No. 5 ·1992-03-11 ·Pages 1093-9

Day WH, McMorris FR

Abstract

Consensus methods are recognized as valuable tools for data analysis, especially when some sort of data aggregation is desired. Although consensus methods for sequences play a vital role in molecular biology, researchers pay little heed to the features and limitations of such methods, and so there are risks that criteria for constructing consensus sequences will be misused or misunderstood. To understand better the issues involved, we conducted a critical comparison of nine consensus methods for sequences, of which eight were used in papers appearing in this journal. We report the results of that comparison, and we make recommendations which we hope will assist researchers when they must select particular consensus methods for particular applications.

MeSH Terms
Algorithms Base Sequence/genetics Consensus Sequence/genetics Data Interpretation, Statistical Evaluation Studies as Topic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Day W H
Department of Computer Science, Memorial University of Newfoundland, St John's, Canada.
McMorris F R
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/20.5.1093
Published
1992-03-11
Pages
1093-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC312096
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/20.5.1093 PMC Full Text View journal details
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