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PMID: 15609021 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Natural antibodies and the autoimmunity of atherosclerosis.

Springer seminars in immunopathology ·Vol. 26 ·No. 4 ·2005-03-00 ·Pages 385-404

Binder CJ, Silverman GJ

Abstract

In recent years, the subject of natural antibodies has been revisited and the immunobiological roles of these humoral factors are being better defined. These antibodies are secreted by distinct sets of innate-like B cells, B-1 cells and marginal zone B cells, which arise early in development to become the sources of "natural immune memory". Due to their interactions with a variety of self-determinants, natural antibodies have previously been postulated to play roles in the maintenance of host homeostasis. A central paradigm has recently been developed from the demonstration that oxidation derived epitopes on apoptotic cells and oxidized low-density lipoproteins are recognized by the phosphorylcholine-specific germline encoded B-1 cell natural antibody, T15, which has provided important insights into possible "house-keeping" functions under both normal and pathological conditions. In this review, the potential functions of natural antibodies in the pathogenesis and progression of the chronic inflammatory condition of atherosclerosis are discussed, as well as their capacities for apoptotic cell binding and clearance. These interactions of natural antibodies and oxidation-epitopes from phospholipids appear to provide a dynamic immunobiological connection linking host responses in infection, autoimmunity and atherosclerosis.

MeSH Terms
Animals Antibodies, Antiphospholipid/biosynthesis Antibody Specificity Apoptosis/immunology Arteriosclerosis/etiology,immunology,pathology Autoantigens Autoimmunity B-Lymphocyte Subsets/immunology Humans Immunity, Innate Lipoproteins, LDL/immunology Mice Models, Immunological Streptococcus pneumoniae/immunology
Chemicals
Antibodies, Antiphospholipid Autoantigens Lipoproteins, LDL oxidized low density lipoprotein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Binder Christoph J
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA.
Silverman Gregg J
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Article Info
Journal
Springer seminars in immunopathology
Abbr.
Springer Semin Immunopathol
ISSN
0344-4325
DOI
10.1007/s00281-004-0185-z
Published
2005-03-00
Pages
385-404
Language
English
Region
Germany
NLM ID
7910384
Subset
IM
Grants
NIAMS NIH HHS · AR47360 · United States
NIAMS NIH HHS · AR50659 · United States
NHLBI NIH HHS · HL56989 · United States
NHLBI NIH HHS · HL69464 · United States
External Links
PubMed source DOI: 10.1007/s00281-004-0185-z
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