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PMID: 15716507 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.

Genetics ·Vol. 169 ·No. 4 ·2005-04-00 ·Pages 2023-34

Lazzaro BP

Abstract

Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome average. These genes also exhibit unusually high levels of segregating nonsynonymous polymorphism in D. melanogaster and D. simulans populations. A fourth Sr-C is comparatively conserved. McDonald-Kreitman tests reveal a significant excess of replacement fixations between D. melanogaster and D. simulans in the Sr-C's, but tests of polymorphic site frequency spectra do not support models of directional selection. It is possible that the molecular functions of SR-C proteins are sufficiently robust to allow exceptionally high amino acid substitution rates without compromising organismal fitness. Alternatively, SR-Cs may evolve under diversifying selection, perhaps as a result of pressure from pathogens. Interestingly, Sr-CIII and Sr-CIV are polymorphic for premature stop codons. Sr-CIV is also polymorphic for an in-frame 101-codon deletion and for the absence of one intron.

MeSH Terms
Animals Codon Codon, Terminator Drosophila/genetics Drosophila melanogaster/genetics Evolution, Molecular Gene Deletion Genetic Variation Genome Introns Linkage Disequilibrium Models, Genetic Models, Statistical Molecular Sequence Data Mutation Phagocytosis Polymorphism, Genetic Receptors, Immunologic/genetics,physiology Receptors, Scavenger Scavenger Receptors, Class C Sequence Analysis, DNA Species Specificity
Chemicals
Codon Codon, Terminator Receptors, Immunologic Receptors, Scavenger Scavenger Receptors, Class C
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lazzaro Brian P
Department of Entomology, Cornell University, Ithaca, New York 14853, USA. [email protected]
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.104.034249
Email
[email protected]
Published
2005-04-00
Epub
2005-00-16
Pages
2023-34
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1449580
Subset
IM
Grants
NIAID NIH HHS · R01 AI046402 · United States
NIAID NIH HHS · AI46402 · United States
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External Links
PubMed source DOI: 10.1534/genetics.104.034249 PMC Full Text View journal details
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