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PMID: 2492668 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 3 ·1989-02-00 ·Pages 958-62

Hughes AL, Nei M

Abstract

To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative antigen-recognition site (included in the first domain of the MHC molecule) and other regions of human and mouse class II genes were examined. In the putative antigen-recognition site, the rate of nonsynonymous substitution was found to exceed that of synonymous substitution, whereas in the second domain the former was significantly lower than the latter. In light of a previous theoretical study and parallel findings in class I MHC loci, we conclude that the unusually high degree of polymorphism at class II MHC loci is caused mainly by overdominant selection (heterozygote advantage) operating in the antigen-recognition site.

MeSH Terms
Alleles Animals Base Sequence Biological Evolution Codon Genes, Dominant Genes, MHC Class II Humans Mice Molecular Sequence Data Polymorphism, Genetic Selection, Genetic Software Species Specificity
Chemicals
Codon
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hughes A L
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.
Nei M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.3.958
Published
1989-02-00
Pages
958-62
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286598
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.3.958 PMC Full Text View journal details
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