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PMID: 12930753 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Natural selection drives Drosophila immune system evolution.

Genetics ·Vol. 164 ·No. 4 ·2003-08-00 ·Pages 1471-80

Schlenke TA, Begun DJ

Abstract

Evidence from disparate sources suggests that natural selection may often play a role in the evolution of host immune system proteins. However, there have been few attempts to make general population genetic inferences on the basis of analysis of several immune-system-related genes from a single species. Here we present DNA polymorphism and divergence data from 34 genes thought to function in the innate immune system of Drosophila simulans and compare these data to those from 28 nonimmunity genes sequenced from the same lines. Several statistics, including average K(A)/K(S) ratio, average silent heterozygosity, and average haplotype diversity, significantly differ between the immunity and nonimmunity genes, suggesting an important role for directional selection in immune system protein evolution. In contrast to data from mammalian immunoglobulins and other proteins, we find no strong evidence for the selective maintenance of protein diversity in Drosophila immune system proteins. This may be a consequence of Drosophila's generalized innate immune response.

MeSH Terms
Animals Chromosomes Codon Drosophila/genetics,immunology Evolution, Molecular Female Gene Frequency Genes, Insect Genetic Linkage Haplotypes Heterozygote Immune System Molecular Sequence Data Mutation Polymorphism, Genetic Selection, Genetic Species Specificity X Chromosome
Chemicals
Codon
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schlenke Todd A
Section of Evolution and Ecology, Division of Biological Sciences, Storer Hall, University of California, Davis, CA 95616, USA. [email protected]
Begun David J
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/164.4.1471
Email
[email protected]
Published
2003-08-00
Pages
1471-80
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1462669
Subset
IM
Grants
NIGMS NIH HHS · GM 55298 · United States
Databases
GENBANK
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PubMed source DOI: 10.1093/genetics/164.4.1471 PMC Full Text View journal details
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