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PMID: 15837812 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation.

The Journal of experimental medicine ·Vol. 201 ·No. 8 ·2005-04-18 ·Pages 1269-79

Jameson JM, Cauvi G, Sharp LL, Witherden DA, Havran WL

Abstract

Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds the surface of leukocytes infiltrating damaged sites. Skin gammadelta T cells play specialized roles in keratinocyte proliferation during wound repair. Here, we show that gammadelta T cells are required for hyaluronan deposition in the extracellular matrix (ECM) and subsequent macrophage infiltration into wound sites. We describe a novel mechanism of control in which gammadelta T cell-derived keratinocyte growth factors induce epithelial cell production of hyaluronan. In turn, hyaluronan recruits macrophages to the site of damage. These results demonstrate a novel function for skin gammadelta T cells in inflammation and provide a new perspective on T cell regulation of ECM molecules.

MeSH Terms
Animals Cell Line Dermis/immunology,injuries Epidermis/immunology,injuries Epithelial Cells/metabolism Gene Expression Regulation, Enzymologic Glucuronosyltransferase/biosynthesis,genetics Hyaluronan Synthases Hyaluronic Acid/biosynthesis,pharmacology Inflammation/immunology Keratinocytes/immunology,metabolism Macrophages/drug effects,immunology Mice Mice, Knockout Neutrophils/immunology Receptors, Antigen, T-Cell, gamma-delta/deficiency,genetics Skin/immunology,injuries,metabolism Subcutaneous Tissue/immunology,injuries T-Lymphocyte Subsets/immunology Wound Healing/immunology
Chemicals
Receptors, Antigen, T-Cell, gamma-delta Hyaluronic Acid Glucuronosyltransferase Hyaluronan Synthases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jameson Julie M
The Scripps Research Institute, La Jolla, CA 92037, USA.
Cauvi Gabrielle
Sharp Leslie L
Witherden Deborah A
Havran Wendy L
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20042057
Published
2005-04-18
Pages
1269-79
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2213158
Subset
IM
Grants
NIAID NIH HHS · 5T43AI-07244 · United States
NIAID NIH HHS · AI-32751 · United States
NIAID NIH HHS · R01 AI036964 · United States
NIAID NIH HHS · T32 AI007244 · United States
NIAID NIH HHS · AI-36964 · United States
External Links
PubMed source DOI: 10.1084/jem.20042057 PMC Full Text View journal details
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