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PMID: 16025107 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.

Nature neuroscience ·Vol. 8 ·No. 8 ·2005-08-00 ·Pages 1022-7

Pfeiffenberger C, Cutforth T, Woods G, Yamada J, Rentería RC, Copenhagen DR, Flanagan JG, Feldheim DA

Abstract

In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.

MeSH Terms
Animals Body Patterning/physiology Brain Mapping Ephrin-A2/deficiency,physiology Ephrin-A3/deficiency,physiology Ephrin-A5/deficiency,physiology Geniculate Bodies/physiology Mice Mice, Knockout Receptor, EphA2/deficiency Receptor, EphA3/deficiency Receptor, EphA5/deficiency Retinal Ganglion Cells/physiology Synaptic Transmission/physiology Visual Pathways/physiology
Chemicals
Ephrin-A2 Ephrin-A3 Ephrin-A5 Receptor, EphA2 Receptor, EphA3 Receptor, EphA5
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Pfeiffenberger Cory
Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA.
Cutforth Tyler
Woods Georgia
Yamada Jena
Rentería René C
Copenhagen David R
Flanagan John G
Feldheim David A
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1097-6256
DOI
10.1038/nn1508
Published
2005-08-00
Epub
2005-00-17
Pages
1022-7
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC1352169
Subset
IM
Grants
NCI NIH HHS · P01 CA023767 · United States
NEI NIH HHS · EY014689 · United States
NIDCD NIH HHS · R01 DC04209 · United States
NIDCD NIH HHS · R01 DC004209 · United States
NIGMS NIH HHS · T32 GM008646 · United States
NCI NIH HHS · P01 CA23767 · United States
NEI NIH HHS · R01 EY014689 · United States
NIGMS NIH HHS · GM08646 · United States
External Links
PubMed source DOI: 10.1038/nn1508 PMC Full Text View journal details
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