Home LiteratureArticle Details
PMID: 1649324 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

SL3-3 enhancer factor 1 transcriptional activators are required for tumor formation by SL3-3 murine leukemia virus.

Journal of virology ·Vol. 65 ·No. 8 ·1991-08-00 ·Pages 4177-81

Hallberg B, Schmidt J, Luz A, Pedersen FS, Grundström T

Abstract

The transcriptional enhancers of retroviruses that lack an oncogene are important determinants of their oncogenicity. However, no specific cellular transcriptional activator has yet been found to determine the oncogenicity for any of these viruses. The SL3-3 enhancer factor 1 (SEF1) cellular transcriptional activators are expressed preferentially in T lymphocytes. In the SL3-3 murine leukemia virus enhancer, two different sequences can bind SEF1 activators. We show that mutation of the SEF1 binding sites disrupts the disease potential of SL3-3 murine leukemia virus, implying that SEF1 transcriptional activators are required for tumor induction by SL3-3. The SEF1 site mutations did not appear to affect the pathogenicity of SL3-3 by impairment of virus multiplication, but rather by a specific defect in the ability of neoplastic transformation.

MeSH Terms
Animals Animals, Newborn Base Sequence Binding Sites Cell Transformation, Neoplastic DNA, Viral/analysis Enhancer Elements, Genetic Leukemia Virus, Murine/genetics,growth & development,physiology Lymphoma/etiology Mice Molecular Sequence Data Mutagenesis, Insertional Mutagenesis, Site-Directed Plasmids Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma/microbiology Proviruses/genetics,physiology Repetitive Sequences, Nucleic Acid Trans-Activators/physiology Transcription, Genetic
Chemicals
DNA, Viral Trans-Activators
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hallberg B
Department of Applied Cell and Molecular Biology, University of Umeå, Sweden.
Schmidt J
Luz A
Pedersen F S
Grundström T
References (26)
26 references, click to expand
  1. Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour.
    Nature. 1981 Jul 9;292(5819):167-70 PMID: 6264322
  2. A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas.
    Nature. 1983 Mar 31-Apr 6;302(5907):445-9 PMID: 6300684
  3. A plaque assay for murine leukemia virus using enzyme-coupled antibodies.
    Virology. 1977 Apr;77(2):849-52 PMID: 193266
  4. Type C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells.
    Science. 1975 Jan 31;187(4174):350-3 PMID: 46123
  5. A new technique for the assay of infectivity of human adenovirus 5 DNA.
    Virology. 1973 Apr;52(2):456-67 PMID: 4705382
  6. Binding of SL3-3 enhancer factor 1 transcriptional activators to viral and chromosomal enhancer sequences.
    J Virol. 1991 Jan;65(1):42-50 PMID: 1985206
  7. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
    Science. 1985 Dec 20;230(4732):1350-4 PMID: 2999980
  8. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.
    Science. 1988 Jan 29;239(4839):487-91 PMID: 2448875
  9. Different relative expression from two murine leukemia virus long terminal repeats in unintegrated transfected DNA and in integrated retroviral vector proviruses.
    J Virol. 1989 Dec;63(12):5201-7 PMID: 2555551
  10. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3.
    Mol Cell Biol. 1988 Apr;8(4):1625-37 PMID: 2837650
  11. Tissue specific sequence motifs in the enhancer of the leukaemogenic mouse retrovirus SL3-3.
    Nucleic Acids Res. 1988 Jul 11;16(13):5927-44 PMID: 2840634
  12. Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types.
    Proc Natl Acad Sci U S A. 1988 Nov;85(21):7952-6 PMID: 2847148
  13. Oncogenic retrovirus from spontaneous murine osteomas. II. Molecular cloning and genomic characterization.
    Virology. 1986 Apr 15;150(1):96-105 PMID: 3006346
  14. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.
    EMBO J. 1985 Jul;4(7):1793-8 PMID: 2992942
  15. Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences.
    J Virol. 1985 Sep;55(3):862-6 PMID: 2991605
  16. Loss of responsiveness of an AP1-related factor, PEBP1, to 12-O-tetradecanoylphorbol-13-acetate after transformation of NIH 3T3 cells by the Ha-ras oncogene.
    J Virol. 1989 Sep;63(9):3669-77 PMID: 2547991
  17. Mutant analysis of protein interactions with a nuclear factor I binding site in the SL3-3 virus enhancer.
    Nucleic Acids Res. 1989 Jun 12;17(11):4061-75 PMID: 2544855
  18. Tissue-specific transcription preference as a determinant of cell tropism and leukaemogenic potential of murine retroviruses.
    Nature. 1984 Nov 8-14;312(5990):159-62 PMID: 6095084
  19. Oncogenic retrovirus from spontaneous murine osteomas. I. Isolation and biological characterization.
    J Gen Virol. 1984 Dec;65 ( Pt 12):2237-48 PMID: 6512505
  20. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer.
    J Virol. 1990 Oct;64(10):4808-19 PMID: 2168969
  21. A single mutation in one of the CORE elements of Moloney murine leukemia virus reduced binding of a 42-kDa T lymphoma cell nuclear factor but did not affect lymphomagenesis.
    Mol Carcinog. 1990;3(2):93-102 PMID: 2346587
  22. Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity.
    Genes Dev. 1990 Feb;4(2):233-42 PMID: 2338244
  23. Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2097-101 PMID: 6326104
  24. Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion.
    Cell. 1984 May;37(1):113-22 PMID: 6327047
  25. Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat.
    Nature. 1984 Mar 29-Apr 4;308(5958):467-70 PMID: 6323995
  26. Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.
    Am J Pathol. 1983 Nov;113(2):237-65 PMID: 6605691
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.8.4177-4181.1991
Published
1991-08-00
Pages
4177-81
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC248852
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.65.8.4177-4181.1991 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2