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PMID: 2992942 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.

The EMBO journal ·Vol. 4 ·No. 7 ·1985-07-00 ·Pages 1793-8

Selten G, Cuypers HT, Berns A

Abstract

Proviral integration near the Pim-1 gene is frequently observed in murine leukemia virus induced T-cell lymphomas in mice. Integration in the Pim-1 domain is associated with the presence of enhanced levels of a Pim-1 mRNA, which is normally expressed as a predominant 2.8 kb species at low levels in lymphoid tissues. The majority of integrations occurred in the 3' region of the Pim-1 transcription unit. This resulted in transcripts ranging in size from 2.0 to 2.6 kb, which were terminated in the 5' proviral LTR. Dependent on the site of integration up to 1300 bases of Pim-1 specific sequences were missing from the modified Pim-1 mRNA in these lymphomas.

MeSH Terms
Animals Cloning, Molecular DNA Restriction Enzymes Leukemia Virus, Murine/genetics Lymphoma/microbiology Mice Mice, Inbred BALB C Nucleic Acid Hybridization Oncogenes T-Lymphocytes Thymus Gland/microbiology Transcription, Genetic
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Selten G
Cuypers H T
Berns A
References (36)
36 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1985-07-00
Pages
1793-8
Language
English
Region
England
NLM ID
8208664
PMCID
PMC554419
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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