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PMID: 6251269 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Characterization of virus produced by a lymphoma induced by inoculation of AKR MCF-247 virus.

Journal of virology ·Vol. 35 ·No. 1 ·1980-07-00 ·Pages 211-8

Pedersen FS, Buchhagen DL, Chen CY, Hays EF, Haseltine WA

Abstract

We report the characterization of the virus produced by a lymphoid cell line derived from a lymphoma of an AKR mouse after injection of the polytropic AKR virus MCF-247. The virus displays polytropic host range properties and is indistinguishable from MCF-247 as judged by analysis of the large RNase T1-resistant oligonucleotides of the RNA genome. Restriction enzyme analysis of cellular DNA revealed the presence of sequences homologous to MCF-247 genomic RNA. The EcoRI cleavage fragments were characteristic of MCF-247 DNA provirus cleavage products.

MeSH Terms
AKR murine leukemia virus/genetics Animals DNA/analysis Electrophoresis, Agar Gel Leukemia Virus, Murine/genetics Lymphoma/microbiology Male Mice Mice, Inbred AKR Neoplasms, Experimental/microbiology Nucleic Acid Hybridization RNA, Viral/analysis Ribonuclease T1
Chemicals
RNA, Viral DNA Ribonuclease T1
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pedersen F S
Buchhagen D L
Chen C Y
Hays E F
Haseltine W A
References (20)
20 references, click to expand
  1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  2. Assay for type C virus in mouse sera based on particulate reverse transcriptase activity.
    J Virol. 1976 Sep;19(3):1107-10 PMID: 61284
  3. Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.
    Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680-4 PMID: 188051
  4. A new class of murine leukemia virus associated with development of spontaneous lymphomas.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92 PMID: 191826
  5. Oncornaviruses produced by murine leukemia cells in culture.
    Virology. 1977 Sep;81(2):363-70 PMID: 197696
  6. Cellular changes in the thymuses of preleukemic AKR mice: correlation with changes in the expression of murine leukemia viruses.
    Cell. 1977 Oct;12(2):341-53 PMID: 199352
  7. Rapid cell culture assay technic for murine leukaemia viruses.
    Nature. 1971 Feb 19;229(5286):564-6 PMID: 4925356
  8. Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.
    J Exp Med. 1972 Feb 1;135(2):429-36 PMID: 4334098
  9. Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.
    Cancer Res. 1973 Dec;33(12):3061-8 PMID: 4357347
  10. Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses.
    Proc Natl Acad Sci U S A. 1978 Jan;75(1):495-9 PMID: 203942
  11. Identification of virus found in mouse lymphomas induced by HIX murine oncornavirus.
    J Virol. 1978 May;26(2):532-5 PMID: 207900
  12. Oncogenicity of AKR endogenous leukemia viruses.
    J Virol. 1978 Jul;27(1):13-8 PMID: 211248
  13. Analysis of unintegrated avian RNA tumor virus double-stranded DNA intermediates.
    J Virol. 1978 Dec;28(3):810-8 PMID: 215781
  14. Phenotypic mixing between murine leukemia viruses: characteristics of ecotropic virus infection of heterologous cells.
    Virology. 1978 Dec;91(2):464-71 PMID: 217158
  15. Properties of "mink cell focus-inducing" (MCF) virus isolated from spontaneous lymphoma lines of BALB/c mice carrying Moloney leukemia virus as an endogenous virus.
    Virology. 1979 Feb;93(1):226-36 PMID: 219598
  16. Restriction enzyme analysis of mouse cellular type C viral DNA: emergence of new viral sequences in spontaneous AKR/J lymphomas.
    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1677-81 PMID: 221902
  17. Identification of DNA fragments carrying ecotropic proviruses of AKR mice.
    Proc Natl Acad Sci U S A. 1979 Sep;76(9):4554-8 PMID: 228301
  18. Isolation of a replication-defective murine leukaemia virus from cultured AKR leukaemia cells.
    Nature. 1979 Dec 13;282(5740):753-4 PMID: 229420
  19. Analysis of the genome of an endogenous, ecotropic retrovirus of the AKR strain of mice: micromethod for detailed characterization of high-molecular-weight RNA.
    J Virol. 1980 Jan;33(1):349-65 PMID: 6245238
  20. A micromethod for detailed characterization of high molecular weight RNA.
    Methods Enzymol. 1980;65(1):680-7 PMID: 6154875
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.35.1.211-218.1980
Published
1980-07-00
Pages
211-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288797
Subset
IM
Grants
NCI NIH HHS · CA-12386 · United States
External Links
PubMed source DOI: 10.1128/JVI.35.1.211-218.1980 PMC Full Text View journal details
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