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PMID: 6605691 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

The American journal of pathology ·Vol. 113 ·No. 2 ·1983-11-00 ·Pages 237-65

Pattengale PK, Taylor CR

Abstract

The present review focuses on the mouse as an experimental immunopathologic model for human non-Hodgkin's lymphomas and related leukemias. Immunomorphologic evidence is presented that clearly demonstrates that B- and T-cell subtypes of mouse (murine) lymphoma/leukemia closely resemble and are analogous to B- and T-cell subtypes of human lymphoma/leukemia as defined by recently proposed immunomorphologic classifications. Further evidence is presented that favors the hypothesis that certain types of murine and human B-cell lymphoma develop out of prodromal, prelymphomatous states, which exhibit antecedent morphologic and immunologic abnormalities. The many experimental advantages of the murine systems are stressed, as well as the concept that the presently defined immunomorphologic approach should be effectively combined with molecular and cytogenetic parameters.

MeSH Terms
Animals B-Lymphocytes/pathology Disease Models, Animal Humans Leukemia/classification Lymphocytes, Null/pathology Lymphoma/classification Lymphoproliferative Disorders/pathology Mice/physiology Mice, Inbred AKR Mice, Inbred C57BL Oncogenes Oncogenic Viruses/genetics Precancerous Conditions/pathology T-Lymphocytes/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pattengale P K
Taylor C R
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1983-11-00
Pages
237-65
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916371
Subset
IM
Grants
NCI NIH HHS · P01-CA19449 · United States
External Links
PubMed source PMC Full Text View journal details
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