Rabbit arthritis induced by cell-free extracts of erysipelothrix.

Infection and immunity ·Vol. 3 ·No. 6 ·1971-06-00 ·Pages 715-22

White TG, Puls JL, Mirikitani FK

Abstract

A cell-free crude extract of Erysipelothrix rhusiopathiae injected intravenously in rabbits induced pathological lesions of the synovial tissue similar to the lesions seen in rheumatoid arthritis. Fluorescence techniques utilizing tagged specific antiserum and fluorescent-tagged antigen injected into nonsensitized rabbits demonstrated the localization of antigen exclusively in the synovium. Localized concentration of fluorescence was demonstrated as early as 1 hr after injection, before histological changes were apparent. After 48 hr, the fluorescence was concentrated in focal areas and early pathological changes characterized as "mesenchymal activation" were observed. A consideration of the significant role of exogenous antigen in the sensitivity arthritides is discussed.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

White T G

Immunology Research Laboratory, U.S. Veterans Administration Hospital, Kansas City, Missouri 64128.

Puls J L

Mirikitani F K

References (11)

11 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.3.6.715-722.1971

Published

1971-06-00

Pages

715-22

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416227

External Links

PubMed source DOI: 10.1128/iai.3.6.715-722.1971 PMC Full Text View journal details

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Rabbit arthritis induced by cell-free extracts of erysipelothrix.

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