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PMID: 16672626 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.

Journal of bacteriology ·Vol. 188 ·No. 10 ·2006-05-00 ·Pages 3721-5

Dheenadhayalan V, Delogu G, Sanguinetti M, Fadda G, Brennan MJ

Abstract

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

MeSH Terms
Antigens, Bacterial/genetics Bacterial Proteins/genetics Gene Expression Regulation, Bacterial Genetic Variation Membrane Proteins/genetics Mycobacterium tuberculosis/genetics,growth & development Protein Isoforms/genetics
Chemicals
Antigens, Bacterial Bacterial Proteins Membrane Proteins PE-PGRS protein, Mycobacterium Protein Isoforms
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dheenadhayalan Veerabadran
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
Delogu Giovanni
Sanguinetti Maurizio
Fadda Giovanni
Brennan Michael J
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.188.10.3721-3725.2006
Published
2006-05-00
Pages
3721-5
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC1482869
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.188.10.3721-3725.2006 PMC Full Text View journal details
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