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PMID: 16787664 Published · ppublish English Journal Article Review

Maternal infection and white matter toxicity.

Neurotoxicology ·Vol. 27 ·No. 5 ·2006-09-00 ·Pages 658-70

Harry GJ, Lawler C, Brunssen SH

Abstract

Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology.

MeSH Terms
Animals Brain/pathology Disease Models, Animal Disease Susceptibility Female Humans Nervous System Diseases/etiology,pathology Pregnancy Pregnancy Complications, Infectious/pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Harry G Jean
Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health/DHHS, Research Triangle Park, NC 27709, USA. [email protected]
Lawler Cindy
Brunssen Susan H
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Article Info
Journal
Neurotoxicology
Abbr.
Neurotoxicology
ISSN
0161-813X
DOI
10.1016/j.neuro.2006.05.004
Email
[email protected]
Published
2006-09-00
Epub
2006-00-17
Pages
658-70
Language
English
Region
Netherlands
NLM ID
7905589
PMCID
PMC1592133
Subset
IM
Grants
NIEHS NIH HHS · Z01 ES021164-09 · United States
External Links
PubMed source DOI: 10.1016/j.neuro.2006.05.004 PMC Full Text View journal details
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