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PMID: 1690126 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

The EMBO journal ·Vol. 9 ·No. 3 ·1990-03-00 ·Pages 907-13

Muller WJ, Lee FS, Dickson C, Peters G, Pattengale P, Leder P

Abstract

The induction of mammary tumors by mouse mammary tumor virus (MMTV) is thought to occur through proviral activation of one or more cellular genes. One of these, int-2, encodes a 27 kd protein which exhibits striking homology to the basic fibroblast growth factor family. To assess directly the role of the int-2 protein in cell proliferation, we have established transgenic mice which carry the int-2 gene driven by the MMTV promoter/enhancer. Expression of the int-2 gene in female transgenic mice results in pronounced mammary gland hyperplasia. Interestingly, expression of the MMTV-int-2 transgene in the prostate gland of male carriers results in a benign, but dramatic, epithelial hyperplasia similar to benign prostatic hypertrophy (BPH), a common but poorly understood disorder in human populations. Together, these results indicate that the int-2 product can act as a potent growth factor in these epithelial tissues.

MeSH Terms
Animals DNA, Viral/genetics Female Fibroblast Growth Factor 3 Fibroblast Growth Factors Gene Expression Genetic Vectors Growth Substances/genetics Male Mammary Glands, Animal/microbiology,pathology Mammary Tumor Virus, Mouse/genetics,isolation & purification Mice Mice, Transgenic Prostate/microbiology,pathology Prostatic Hyperplasia/microbiology,pathology Proto-Oncogene Proteins/genetics,physiology Restriction Mapping
Chemicals
DNA, Viral Fgf3 protein, mouse Fibroblast Growth Factor 3 Growth Substances Proto-Oncogene Proteins Fibroblast Growth Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Muller W J
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.
Lee F S
Dickson C
Peters G
Pattengale P
Leder P
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1990-03-00
Pages
907-13
Language
English
Region
England
NLM ID
8208664
PMCID
PMC551751
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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