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PMID: 1704191 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.

The American journal of pathology ·Vol. 138 ·No. 2 ·1991-02-00 ·Pages 385-93

Rice GE, Munro JM, Corless C, Bevilacqua MP

Abstract

Inducible cell adhesion molecule 110 (INCAM-110), is a 110-kd adhesion receptor for lymphocytes and monocytes identified on cytokine-activated endothelium. Using immunoperoxidase techniques, little or no INCAM-110 was detected on endothelium in normal human tissues. In contrast, INCAM-110 was expressed in postcapillary venules in a variety of active inflammatory processes. In acute appendicitis, INCAM-110 was found coincident with strong expression of endothelial leukocyte adhesion molecule 1 (ELAM-1), a cytokine-inducible molecule that functions in neutrophil adhesion. However, in certain chronic inflammatory processes (eg, sarcoidosis), INCAM-110 was observed without simultaneous ELAM-1 expression. Anti-INCAM-110 antibody E1/6 also marked several extravascular cell types, including lymphoid dendritic cells, some tissue macrophages, synovial lining cells, and reactive mesothelial cells. These data suggest a role for endothelial INCAM-110 in the pathophysiology of both acute and chronic inflammatory reactions. Furthermore INCAM-110 may function as an adhesion molecule for mononuclear leukocytes in a variety of extravascular sites.

MeSH Terms
Acute Disease Blood Vessels/metabolism Cell Adhesion Cell Adhesion Molecules/metabolism Humans Inflammation/metabolism,pathology,physiopathology Leukocytes, Mononuclear/physiology Lymphadenitis/metabolism Lymphoid Tissue/metabolism Reference Values Skin Diseases/metabolism Synovitis/metabolism Vascular Cell Adhesion Molecule-1
Chemicals
Cell Adhesion Molecules Vascular Cell Adhesion Molecule-1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rice G E
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Munro J M
Corless C
Bevilacqua M P
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1991-02-00
Pages
385-93
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886196
Subset
IM
Grants
NHLBI NIH HHS · P01-HL36028 · United States
NHLBI NIH HHS · T32-HL07627 · United States
External Links
PubMed source PMC Full Text View journal details
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