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PMID: 17069877 Published · ppublish English Journal Article Review

Estrogen-BDNF interactions: implications for neurodegenerative diseases.

Frontiers in neuroendocrinology ·Vol. 27 ·No. 4 ·2006-12-00 ·Pages 404-14

Sohrabji F, Lewis DK

Abstract

Since its' discovery over 20 years ago, BDNF has been shown to play a key role in neuronal survival, in promoting neuronal regeneration following injury, regulating transmitter systems and attenuating neural-immune responses. Estrogen's actions in the young and mature brain, and its role in neurodegenerative diseases in many cases overlaps with those observed for BDNF. Reduced estrogen and BDNF are observed in patients with Parkinson's disease and Alzheimer's disease, while high estrogen levels are a risk factor for development of multiple sclerosis. Estrogen receptors, which transduce the actions of estrogen, colocalize to cells that express BDNF and its receptor trkB, and estrogen further regulates the expression of this neurotrophin system. This review describes the distribution of BDNF and trkB expressing cells in the forebrain, and the roles of estrogen and the BDNF-trkB neurotrophin system in Parkinson's disease, Alzheimer's disease and multiple sclerosis.

MeSH Terms
Aging/physiology Alzheimer Disease/pathology,physiopathology Animals Brain-Derived Neurotrophic Factor/physiology Estrogens/physiology Humans Nerve Growth Factors/physiology Neurodegenerative Diseases/physiopathology Parkinson Disease/pathology,physiopathology Receptor, trkB/physiology
Chemicals
Brain-Derived Neurotrophic Factor Estrogens Nerve Growth Factors Receptor, trkB
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sohrabji Farida
Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843-1114, USA. [email protected]
Lewis Danielle K
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Article Info
Journal
Frontiers in neuroendocrinology
Abbr.
Front Neuroendocrinol
ISSN
0091-3022
DOI
10.1016/j.yfrne.2006.09.003
Email
[email protected]
Published
2006-12-00
Epub
2006-00-27
Pages
404-14
Language
English
Region
United States
NLM ID
7513292
PMCID
PMC1828910
Subset
IM
Grants
NIA NIH HHS · R01 AG019515 · United States
NIA NIH HHS · R01 AG027684 · United States
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PubMed source DOI: 10.1016/j.yfrne.2006.09.003 PMC Full Text View journal details
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