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PMID: 17132792 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Cardiac defibrillation and the role of mechanoelectric feedback in postshock arrhythmogenesis.

Annals of the New York Academy of Sciences ·Vol. 1080 ·2006-10-00 ·Pages 320-33

Gurev V, Maleckar MM, Trayanova NA

Abstract

Ventricular dilatation increases the defibrillation threshold (DFT). In order to elucidate the mechanisms responsible for this increase, the present article investigates changes in the postshock behavior of the myocardium upon stretch. A two-dimensional electro-mechanical model of cardiac tissue incorporating heterogeneous fiber orientation was used to explore the effect of sustained stretch on postshock behavior via (a) recruitment of mechanosensitive channels (MSC) and (b) tissue deformation and concomitant changes in tissue conductivities. Recruitment of MSC had no influence on vulnerability to electric shocks as compared to control, but increased the complexity of postshock VF patterns. Stretch-induced deformation and changes in tissue conductivities resulted in a decrease in vulnerability to electric shocks.

MeSH Terms
Arrhythmias, Cardiac/physiopathology Electrodes Electroporation Heart/physiopathology Humans
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gurev Viatcheslav
Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 201, Baltimore, MD 21218, USA.
Maleckar Mary M
Trayanova Natalia A
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Article Info
Journal
Annals of the New York Academy of Sciences
Abbr.
Ann N Y Acad Sci
ISSN
0077-8923
DOI
10.1196/annals.1380.024
Published
2006-10-00
Pages
320-33
Language
English
Region
United States
NLM ID
7506858
PMCID
PMC2925201
Subset
IM
Grants
NHLBI NIH HHS · R01 HL063195 · United States
NHLBI NIH HHS · R01 HL 67322 · United States
NHLBI NIH HHS · R01 HL082729-01A1 · United States
NHLBI NIH HHS · R01 HL082729 · United States
NHLBI NIH HHS · R01 HL063195-05 · United States
NHLBI NIH HHS · R01 HL 63195 · United States
NHLBI NIH HHS · R01 HL067322 · United States
External Links
PubMed source DOI: 10.1196/annals.1380.024 PMC Full Text View journal details
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