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PMID: 1717256 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.

The EMBO journal ·Vol. 10 ·No. 10 ·1991-10-00 ·Pages 2905-10

Lu M, Gong ZY, Shen WF, Ho AD

Abstract

The t(10;14)(q24;q11) chromosomal translocation found in malignant cells of 5-10% of patients with T-cell acute lymphoblastic leukemia (T-ALL) involves the T-cell receptor delta chain gene on chromosome 14 and a breakpoint cluster region on chromosome 10. The candidate proto-oncogene tcl-3, thought to be involved in the pathogenesis of t(10;14) T-ALL, was cloned and found to be elevated in expression in leukemic cells harboring the t(10;14) translocation. Sequence analysis revealed that tcl-3 is a new homeobox-containing gene. Comparison of the tcl-3 cDNA and its 5' genomic sequences with DNA sequences from the t(10;14) translocation breakpoints showed that this gene is structurally altered in four patients with t(10;14)(q24;q11) T-ALL. These findings suggest that homeobox-containing genes that normally act as transcription factors may contribute to T-cell leukemogenesis when abnormally expressed.

Related Genes
tcl-3
MeSH Terms
Amino Acid Sequence Base Sequence Blotting, Northern Chromosome Walking Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 14 DNA/genetics Genes, Homeobox Humans Leukemia-Lymphoma, Adult T-Cell/genetics Molecular Sequence Data Proto-Oncogene Mas Proto-Oncogenes RNA/analysis Restriction Mapping Translocation, Genetic
Chemicals
MAS1 protein, human Proto-Oncogene Mas RNA DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lu M
Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada.
Gong Z Y
Shen W F
Ho A D
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35 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1991-10-00
Pages
2905-10
Language
English
Region
England
NLM ID
8208664
PMCID
PMC453003
Subset
IM
Databases
GENBANK
M62626, S57798, S57800, S58268, S58277, S60920, X56822, X60658, X60659, X60660, X60661
External Links
PubMed source PMC Full Text View journal details
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