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PMID: 1727502 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat.

Journal of virology ·Vol. 66 ·No. 1 ·1992-01-00 ·Pages 586-90

Ghosh D

Abstract

Previous reports (P. D. Katsanakis, C. E. Sekaris, and D. A. Spandidos, Anticancer Res. 11:381-383, 1991; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; R. Miksicek, A. Heber, W. Schmid, U. Danesch, G. Posseckert, M. Beato, and G. Schutz, Cell 46:283-290, 1986) have suggested the existence of a glucocorticoid response element in the long terminal repeat of human immunodeficiency virus (HIV) type 1. This study demonstrated a sequence-specific interaction of the glucocorticoid receptor DNA-binding domain with the previously predicted HIV glucocorticoid response element. This interaction may be relevant to the steroid responsiveness of HIV (P. A. Furth, H. Westphal, and L. Hennighausen, AIDS Res. Hum. Retroviruses 6:553-560, 1990; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; J. Laurence, H. Cooke, and S. K. Sikder, Blood 75:696-703, 1990; D. A. Spandidos, V. Zoounpovilis, A. Kotsinas, C. Tsiripotis, and C. E. Sekeris, Anticancer Res. 10:1241-1246, 1990).

MeSH Terms
Base Sequence Binding Sites DNA, Viral/metabolism HIV Long Terminal Repeat Molecular Sequence Data Receptors, Glucocorticoid/metabolism
Chemicals
DNA, Viral Receptors, Glucocorticoid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ghosh D
National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.1.586-590.1992
Published
1992-01-00
Pages
586-90
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC238321
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.66.1.586-590.1992 PMC Full Text View journal details
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