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PMID: 173263 Published · ppublish English Comparative Study Journal Article

Inhibition of Newcastle disease virus-induced fever in rabbits by cycloheximide.

Archives of virology ·Vol. 48 ·No. 4 ·1975-00-00 ·Pages 367-73

Siegert R, Philipp-Dormston WK, Radsak K, Menzel H

Abstract

Pretreatment with cycloheximide prevents virus-induced fever in rabbits. Compared to the febrile control animals, CH-pretreated afebrile animals exhibit similar concentrations of endogenous pyrogen in the blood and of prostaglandins of the E-group and adenosine 3', 5'-cycle monophosphate in the cerebrospinal fluid. The fever response seems to involve one or several additional so far unknown mediators which are sensitive to cycloheximide.

MeSH Terms
Animals Cyclic AMP/cerebrospinal fluid Cycloheximide/therapeutic use Fever/prevention & control Injections, Intravenous Newcastle disease virus Prostaglandins E/cerebrospinal fluid Pyrogens/blood Rabbits Sodium Chloride/therapeutic use
Chemicals
Prostaglandins E Pyrogens Sodium Chloride Cycloheximide Cyclic AMP
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Siegert R
Philipp-Dormston W K
Radsak K
Menzel H
References (19)
19 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01317435
Published
1975-00-00
Pages
367-73
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01317435 View journal details
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