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PMID: 17429043 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Inositol trisphosphate receptor Ca2+ release channels.

Physiological reviews ·Vol. 87 ·No. 2 ·2007-04-00 ·Pages 593-658

Foskett JK, White C, Cheung KH, Mak DO

Abstract

The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R.

MeSH Terms
Animals Calcium/metabolism Calcium Channels/metabolism Calcium Signaling/physiology Electrophysiology Humans Inositol 1,4,5-Trisphosphate Receptors/metabolism Ion Channel Gating/physiology
Chemicals
Calcium Channels Inositol 1,4,5-Trisphosphate Receptors Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Foskett J Kevin
Department of Physiology, University of Pennsylvania, Philadelphia 19104-6085, USA. [email protected]
White Carl
Cheung King-Ho
Mak Don-On Daniel
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Article Info
Journal
Physiological reviews
Abbr.
Physiol Rev
ISSN
0031-9333
DOI
10.1152/physrev.00035.2006
Email
[email protected]
Published
2007-04-00
Pages
593-658
Language
English
Region
United States
NLM ID
0231714
PMCID
PMC2901638
Subset
IM
Grants
NIMH NIH HHS · R01 MH059937-07 · United States
NIGMS NIH HHS · R01 GM056328-09 · United States
NIMH NIH HHS · R01 MH059937-08 · United States
NIGMS NIH HHS · R01 GM056328-07 · United States
NIGMS NIH HHS · R01 GM056328-06 · United States
NIMH NIH HHS · R01 MH059937 · United States
NIMH NIH HHS · R01 MH059937-09 · United States
NIGMS NIH HHS · R01 GM056328 · United States
NIGMS NIH HHS · R01 GM056328-08 · United States
NIGMS NIH HHS · R01 GM074999 · United States
External Links
PubMed source DOI: 10.1152/physrev.00035.2006 PMC Full Text View journal details
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