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PMID: 1773951 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.

Gut ·Vol. 32 ·No. 12 ·1991-12-00 ·Pages 1473-7

Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI

Abstract

The production of tumour necrosis factor alpha (TNF alpha) and interleukin-6 by human antral mucosa during short term culture in vitro has been measured by enzyme linked immunosorbent assay. TNF alpha and interleukin-6 concentrations in culture supernatants were significantly greater (p less than 0.001) in patients infected with Helicobacter pylori, all of whom had chronic gastritis, than in patients who were H pylori negative with histologically normal gastric mucosa. Among H pylori colonised patients, TNF alpha concentrations were significantly higher in those with active gastritis and neutrophil infiltration into the epithelium than in those with inactive gastritis. In contrast, interleukin-6 concentrations were raised in both active and inactive gastritis. This study shows that H pylori gastritis is associated with increased gastric mucosal production of TNF alpha and interleukin-6 and that the nature of the mucosal cytokine response varies with the immunohistology of the disease. Inflammatory cytokines generated locally within the gastric mucosa could be relevant to the gastric physiology of H pylori infection.

MeSH Terms
Adult Aged Chronic Disease Culture Techniques Gastric Mucosa/immunology,metabolism Gastritis/immunology,metabolism,microbiology Helicobacter Infections/immunology,metabolism Helicobacter pylori Humans Interleukin-6/biosynthesis Middle Aged Tumor Necrosis Factor-alpha/biosynthesis
Chemicals
Interleukin-6 Tumor Necrosis Factor-alpha
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Crabtree J E
Department of Medicine, St James's University Hospital, Leeds, UK.
Shallcross T M
Heatley R V
Wyatt J I
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.32.12.1473
Published
1991-12-00
Pages
1473-7
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1379245
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.32.12.1473 PMC Full Text View journal details
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