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PMID: 17828470 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Chemokines in tumor angiogenesis and metastasis.

Cancer metastasis reviews ·Vol. 26 ·No. 3-4 ·2007-12-00 ·Pages 453-67

Singh S, Sadanandam A, Singh RK

Abstract

Chemokines are a large group of low molecular weight cytokines that are known to selectively attract and activate different cell types. Although the primary function of chemokines is well recognized as leukocyte attractants, recent evidences indicate that they also play a role in number of tumor-related processes, such as growth, angiogenesis and metastasis. Chemokines activate cells through cell surface seven trans-membranes, G-protein-coupled receptors (GPCR). The role played by chemokines and their receptors in tumor pathophysiology is complex as some chemokines favor tumor growth and metastasis, while others may enhance anti-tumor immunity. These diverse functions of chemokines establish them as key mediators between the tumor cells and their microenvironment and play critical role in tumor progression and metastasis. In this review, we present some of the recent advances in chemokine research with special emphasis on its role in tumor angiogenesis and metastasis.

MeSH Terms
Animals Chemokines/physiology Humans Neoplasm Metastasis Neoplasms/blood supply,pathology Neovascularization, Pathologic/etiology Receptors, Chemokine/physiology Signal Transduction
Chemicals
Chemokines Receptors, Chemokine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Singh Seema
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5845, USA.
Sadanandam Anguraj
Singh Rakesh K
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/s10555-007-9068-9
Published
2007-12-00
Pages
453-67
Language
English
Region
Netherlands
NLM ID
8605731
PMCID
PMC4237067
Subset
IM
Grants
NCI NIH HHS · R01 CA072781 · United States
NCI NIH HHS · R01 CA072781-08 · United States
NCI NIH HHS · R29 CA072781 · United States
NCI NIH HHS · CA72781 · United States
External Links
PubMed source DOI: 10.1007/s10555-007-9068-9 PMC Full Text View journal details
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