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PMID: 18063722 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Interspecies interactions within oral microbial communities.

Microbiology and molecular biology reviews : MMBR ·Vol. 71 ·No. 4 ·2007-12-00 ·Pages 653-70

Kuramitsu HK, He X, Lux R, Anderson MH, Shi W

Abstract

While reductionism has greatly advanced microbiology in the past 400 years, assembly of smaller pieces just could not explain the whole! Modern microbiologists are learning "system thinking" and "holism." Such an approach is changing our understanding of microbial physiology and our ability to diagnose/treat microbial infections. This review uses oral microbial communities as a focal point to describe this new trend. With the common name "dental plaque," oral microbial communities are some of the most complex microbial floras in the human body, consisting of more than 700 different bacterial species. For a very long time, oral microbiologists endeavored to use reductionism to identify the key genes or key pathogens responsible for oral microbial pathogenesis. The limitations of reductionism forced scientists to begin adopting new strategies using emerging concepts such as interspecies interaction, microbial community, biofilms, polymicrobial disease, etc. These new research directions indicate that the whole is much more than the simple sum of its parts, since the interactions between different parts resulted in many new physiological functions which cannot be observed with individual components. This review describes some of these interesting interspecies-interaction scenarios.

MeSH Terms
Bacteria/genetics,isolation & purification,pathogenicity Bacterial Physiological Phenomena Biofilms/growth & development Dental Plaque/microbiology,therapy Genome, Bacterial/genetics Humans Mouth/microbiology Periodontal Diseases/microbiology,therapy Polymerase Chain Reaction Research/trends Virulence
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kuramitsu Howard K
Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA.
He Xuesong
Lux Renate
Anderson Maxwell H
Shi Wenyuan
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.00024-07
Published
2007-12-00
Pages
653-70
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC2168648
Subset
IM
Grants
NIMHD NIH HHS · MD01831 · United States
NIGMS NIH HHS · R01 GM054666 · United States
NIMHD NIH HHS · R41 MD001831 · United States
NIDCR NIH HHS · DE09821 · United States
NIDCR NIH HHS · R01 DE009821 · United States
NIDCR NIH HHS · R01 DE003258 · United States
NIGMS NIH HHS · GM54666 · United States
NIDCR NIH HHS · DE03258 · United States
NIMHD NIH HHS · R42 MD001831 · United States
External Links
PubMed source DOI: 10.1128/MMBR.00024-07 PMC Full Text View journal details
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