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PMID: 18226091 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

SIRT6 in DNA repair, metabolism and ageing.

Journal of internal medicine ·Vol. 263 ·No. 2 ·2008-02-00 ·Pages 128-41

Lombard DB, Schwer B, Alt FW, Mostoslavsky R

Abstract

Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1-like signalling. In addition, homologs of yeast Sir2--the sirtuins--regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [Cell (2006) 124:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.

MeSH Terms
Aging/metabolism Animals DNA Repair/physiology Longevity Mice Mice, Knockout Models, Biological Phenotype Sirtuins/metabolism
Chemicals
Sirtuins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lombard D B
Howard Hughes Medical Institute, The Children's Hospital, CBR Institute for Biomedical Research, Boston, MA, USA.
Schwer B
Alt F W
Mostoslavsky R
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Article Info
Journal
Journal of internal medicine
Abbr.
J Intern Med
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2007.01902.x
Published
2008-02-00
Pages
128-41
Language
English
Region
England
NLM ID
8904841
PMCID
PMC2486832
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1111/j.1365-2796.2007.01902.x PMC Full Text View journal details
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