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PMID: 18347592 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Review

Comparing whole genomes using DNA microarrays.

Nature reviews. Genetics ·Vol. 9 ·No. 4 ·2008-04-00 ·Pages 291-302

Gresham D, Dunham MJ, Botstein D

Abstract

The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.

MeSH Terms
Animals Chromosome Mapping Gene Dosage Genetic Variation Genome Genomics/methods,statistics & numerical data Humans Oligonucleotide Array Sequence Analysis/methods,statistics & numerical data Polymorphism, Single Nucleotide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gresham David
Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey 08544, USA. [email protected]
Dunham Maitreya J
Botstein David
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2335
Email
[email protected]
Published
2008-04-00
Pages
291-302
Language
English
Region
England
NLM ID
100962779
PMCID
PMC7097741
Subset
IM
Grants
NIGMS NIH HHS · P50 GM071508 · United States
NIGMS NIH HHS · R01 GM046406 · United States
NIGMS NIH HHS · R01 GM107466 · United States
NIGMS NIH HHS · GM-071508 · United States
External Links
PubMed source DOI: 10.1038/nrg2335 PMC Full Text View journal details
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