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PMID: 18438464 Published · ppublish English Journal Article

Pcbs and tight junction expression.

Environmental toxicology and pharmacology ·Vol. 25 ·No. 2 ·2008-03-00 ·Pages 234-40

Eum SY, András IE, Couraud PO, Hennig B, Toborek M

Abstract

Polychlorinated biphenyl (PCB) congeners exhibit a broad range of adverse biological effects including neurotoxicity. The mechanisms by which PCBs cause neurotoxic effects are still not completely understood. The blood-brain barrier (BBB) is a physical and metabolic barrier separating brain microenvironment from the peripheral circulation and is mainly composed of endothelial cells connected by tight junctions. We examined the effects of several highly-chlorinated PCB congeners on expression of tight junction proteins in human brain endothelial cells. Treatment for 24 h with selective PCB congeners disrupted expression of the cytosolic scaffold proteins of tight junctions, such as zonula occludens (ZO)-1, ZO-2, and AF6. In contrast, PCB exposure did not alter expression of integral membrane proteins, junctional adhesion molecule-A (JAM-A), and claudin-1. Based on these data, we suggest that PCB-mediated selective alterations of tight junction protein expression may contribute to their neurotoxic effects in the central nervous system.

Keywords
Polychlorinated biphenyls blood-brain barrier tight junctions zonula occludens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Eum Sung Yong
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, KY 40536.
András Ibolya E
Couraud Pierre-Olivier
Hennig Bernhard
Toborek Michal
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Article Info
Journal
Environmental toxicology and pharmacology
Abbr.
Environ Toxicol Pharmacol
ISSN
1382-6689
DOI
10.1016/j.etap.2007.10.019
Published
2008-03-00
Pages
234-40
Language
English
Region
Netherlands
NLM ID
9612020
PMCID
PMC2346445
Grants
NIMH NIH HHS · R01 MH063022 · United States
NIEHS NIH HHS · P42 ES007380 · United States
NIEHS NIH HHS · P42 ES007380-119005 · United States
NIDA NIH HHS · R01 DA027569 · United States
NINDS NIH HHS · R01 NS039254 · United States
NIMH NIH HHS · R01 MH098891 · United States
NIMH NIH HHS · R01 MH072567 · United States
NIEHS NIH HHS · P42 ES007380-110007 · United States
External Links
PubMed source DOI: 10.1016/j.etap.2007.10.019 PMC Full Text View journal details
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