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PMID: 1846140 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.

Journal of bacteriology ·Vol. 173 ·No. 1 ·1991-01-00 ·Pages 86-93

Pulkkinen WS, Miller SI

Abstract

The phoP-phoQ-regulated pagC locus is essential for full virulence and survival within macrophages of Salmonella typhimurium. The protein product, DNA sequence, and transcript of pagC were determined. The pagC locus encodes a single 188-amino-acid membrane protein that is similar to the ail-encoded eucaryotic cell invasion protein of Yersinia enterocolitica and the lom-encoded protein of bacteriophage lambda. The similarity of PagC and Ail to Lom leads us to hypothesize that Lom is a virulence protein and that bacteriophage gene transfer and lysogeny could have led to the development of proteins essential to survival within macrophages and eucaryotic cell invasion.

MeSH Terms
Adhesins, Bacterial Amino Acid Sequence Bacterial Proteins/genetics,isolation & purification Base Sequence Blotting, Western Cloning, Molecular Cosmids DNA Transposable Elements DNA, Bacterial/genetics Electrophoresis, Gel, Two-Dimensional Genes, Bacterial Information Systems Membrane Proteins Molecular Sequence Data Restriction Mapping Salmonella typhimurium/genetics,pathogenicity Sequence Homology, Nucleic Acid Virulence/genetics Yersinia enterocolitica/genetics,pathogenicity
Chemicals
Adhesins, Bacterial Bacterial Proteins DNA Transposable Elements DNA, Bacterial Membrane Proteins invasin, Yersinia pagC protein, Salmonella typhimurium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pulkkinen W S
Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Miller S I
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.173.1.86-93.1991
Published
1991-01-00
Pages
86-93
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC207160
Subset
IM
Grants
NIAID NIH HHS · AI00917-01 · United States
Databases
GENBANK
M55546, M63255, M63305, M63306, M64332, S69596, S69601, S69604, S69828, S69830
External Links
PubMed source DOI: 10.1128/jb.173.1.86-93.1991 PMC Full Text View journal details
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