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PMID: 18485096 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The Yin and Yang of YY1 in the nervous system.

Journal of neurochemistry ·Vol. 106 ·No. 4 ·2008-08-00 ·Pages 1493-502

He Y, Casaccia-Bonnefil P

Abstract

The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis. This review will focus on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease. The multiple functions of YY1 in distinct cell types are reviewed and the possible mechanisms underlying the cell specificity for these functions are discussed.

MeSH Terms
Animals Humans Myelin Sheath/chemistry,metabolism,physiology Nervous System/chemistry,embryology,metabolism Nervous System Diseases/metabolism,pathology,physiopathology Neurons/cytology,metabolism,physiology YY1 Transcription Factor/chemistry,physiology
Chemicals
YY1 Transcription Factor YY1 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
He Ye
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA. [email protected]
Casaccia-Bonnefil Patrizia
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Article Info
Journal
Journal of neurochemistry
Abbr.
J Neurochem
ISSN
1471-4159
DOI
10.1111/j.1471-4159.2008.05486.x
Email
[email protected]
Published
2008-08-00
Epub
2008-00-15
Pages
1493-502
Language
English
Region
England
NLM ID
2985190R
PMCID
PMC2642738
Subset
IM
Grants
NINDS NIH HHS · R01NS052738 · United States
NINDS NIH HHS · R01 NS042925-06 · United States
NINDS NIH HHS · R01 NS052738 · United States
NINDS NIH HHS · R01 NS042925 · United States
NINDS NIH HHS · R01 NS052738-02 · United States
NINDS NIH HHS · R01 NS042925-05A1 · United States
NINDS NIH HHS · R01NS042925 · United States
External Links
PubMed source DOI: 10.1111/j.1471-4159.2008.05486.x PMC Full Text View journal details
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