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PMID: 18544499 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

New insights into mechanism and regulation of actin capping protein.

International review of cell and molecular biology ·Vol. 267 ·2008-00-00 ·Pages 183-206

Cooper JA, Sept D

Abstract

The heterodimeric actin capping protein, referred to here as "CP," is an essential element of the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their polymerization. In vitro, CP has a critical role in the dendritic nucleation process of actin assembly mediated by Arp2/3 complex, and in vivo, CP is important for actin assembly and actin-based process of morphogenesis and differentiation. Recent studies have provided new insight into the mechanism of CP binding the barbed end, which raises new possibilities for the dynamics of CP and actin in cells. In addition, a number of molecules that bind and regulate CP have been discovered, suggesting new ideas for how CP may integrate into diverse processes of cell physiology.

MeSH Terms
Actin Capping Proteins/chemistry,classification,genetics,metabolism Actins/metabolism Adaptor Proteins, Signal Transducing/metabolism Animals Carrier Proteins/metabolism Cell Membrane/metabolism Cytoskeletal Proteins/metabolism Dynactin Complex Intercellular Signaling Peptides and Proteins/metabolism Microfilament Proteins Microtubule-Associated Proteins/metabolism Models, Molecular Phylogeny Protein Conformation Protein Isoforms/chemistry,classification,genetics,metabolism Protein Subunits/chemistry,genetics,metabolism Sarcomeres/metabolism,ultrastructure
Chemicals
Actin Capping Proteins Actins Adaptor Proteins, Signal Transducing CD2-associated protein Carmil1 protein, mouse Carrier Proteins Cytoskeletal Proteins Dynactin Complex Intercellular Signaling Peptides and Proteins Microfilament Proteins Microtubule-Associated Proteins Protein Isoforms Protein Subunits myotrophin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cooper John A
Department of Cell Biology, Washington University, St. Louis, MO 63110, USA.
Sept David
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Article Info
Journal
International review of cell and molecular biology
Abbr.
Int Rev Cell Mol Biol
ISSN
1937-6448
DOI
10.1016/S1937-6448(08)00604-7
Published
2008-00-00
Pages
183-206
Language
English
Region
Netherlands
NLM ID
101475846
PMCID
PMC2583073
Subset
IM
Grants
NIGMS NIH HHS · R01 GM038542 · United States
NIGMS NIH HHS · R01 GM038542-20 · United States
NIGMS NIH HHS · GM 67426 · United States
NIGMS NIH HHS · GM 38542 · United States
External Links
PubMed source DOI: 10.1016/S1937-6448(08)00604-7 PMC Full Text View journal details
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