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PMID: 18692595 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Endothelial nitric oxide (NO) and its pathophysiologic regulation.

Vascular pharmacology ·Vol. 49 ·No. 4-6 ·2008-00-00 ·Pages 134-40

Chatterjee A, Black SM, Catravas JD

Abstract

Nitric oxide (NO) is a gaseous lipophilic free radical generated by three distinct isoforms of nitric oxide synthases (NOS), type 1 or neuronal (nNOS), type 2 or inducible (iNOS) and type 3 or endothelial NOS (eNOS). Expression of eNOS is altered in many types of cardiovascular disease, such as atherosclerosis, diabetes and hypertension. The ubiquitous chaperone heat shock protein 90 (hsp90) associates with NOS and is important for its proper folding and function. Current studies point toward a therapeutic potential by modulating hsp90-NOS association in various vascular diseases. Here we review the transcriptional regulation of endothelial NOS and factors affecting eNOS activity and function, as well as the important vascular pathologies associated with altered NOS function, focusing on the regulatory role of hsp90 and other factors in NO-associated pathogenesis of these diseases.

MeSH Terms
Animals Endothelium, Vascular/metabolism,physiopathology Gene Expression Regulation, Enzymologic HSP90 Heat-Shock Proteins/metabolism Humans Nitric Oxide/biosynthesis,physiology Nitric Oxide Synthase Type III/genetics,metabolism Vascular Diseases/metabolism,physiopathology
Chemicals
HSP90 Heat-Shock Proteins Nitric Oxide Nitric Oxide Synthase Type III
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chatterjee Anuran
Pulmonary Vascular Disease Program, Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500, USA.
Black Stephen M
Catravas John D
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Article Info
Journal
Vascular pharmacology
Abbr.
Vascul Pharmacol
ISSN
1537-1891
DOI
10.1016/j.vph.2008.06.008
Published
2008-00-00
Epub
2008-00-20
Pages
134-40
Language
English
Region
United States
NLM ID
101130615
PMCID
PMC2592563
Subset
IM
Grants
NHLBI NIH HHS · R01 HL070214 · United States
NHLBI NIH HHS · R01 HL070214-04 · United States
NHLBI NIH HHS · HL 70142 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1016/j.vph.2008.06.008 PMC Full Text View journal details
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