The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells.

The Journal of experimental medicine ·Vol. 145 ·No. 1 ·1977-01-01 ·Pages 163-74

Kong AS, Morse SI

Abstract

The mitogenic response of murine lymphocytes to the lymphocytosis-promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. The selectivity of responsiveness to LPF with respect to the population of T cells which is stimllated, differs from that of PHA as well as Con A, and the surface receptors are different. A population of adherent cells, which does not appear to consist of macrophages or other phagocytic cells, is required for the T-cell response.

MeSH Terms

Animals Antilymphocyte Serum Bacterial Proteins/pharmacology Bordetella pertussis/immunology Cell Adhesion Concanavalin A/pharmacology Female Isoantigens Lectins/pharmacology Lymphocyte Activation Lymphocytosis/immunology Macrophages/immunology Mercaptoethanol/pharmacology Mice Mice, Inbred Strains Mice, Nude Microscopy, Electron Spleen/immunology,ultrastructure T-Lymphocytes/immunology

Chemicals

Antilymphocyte Serum Bacterial Proteins Isoantigens Lectins Concanavalin A Mercaptoethanol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kong A S

Morse S I

References (27)

27 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.145.1.163

Published

1977-01-01

Pages

163-74

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180588

Subset

External Links

PubMed source DOI: 10.1084/jem.145.1.163 PMC Full Text View journal details

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The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells.

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