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PMID: 187715 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. I. Proliferative response.

The Journal of experimental medicine ·Vol. 145 ·No. 1 ·1977-01-01 ·Pages 151-62

Kong AS, Morse SI

Abstract

The lymphocytosis-promoting factor of Bordetella pertussis is a potent mitogen for murine lymphocytes in vitro. The stimulatory response was not the result of specific antigen stimulation. Spleen and lymph node cells were responsive, whereas normal thymocytes were unresponsive. However, DNA replication was induced in cortisone-resistant thymocytes by lymphocytosis-promoting factor (LPF). Bone marrow cells were not stimulated by LPF.

MeSH Terms
Animals Antigen-Antibody Reactions Bacterial Proteins/immunology,pharmacology Bone Marrow/drug effects Bone Marrow Cells Bordetella pertussis/immunology Clone Cells Concanavalin A/pharmacology Cortisone/pharmacology Female Kinetics Lectins/pharmacology Lymph Nodes/immunology Lymphocyte Activation/drug effects Lymphocytes/drug effects Lymphocytosis/immunology Mice Mice, Inbred CBA Mice, Inbred Strains Spleen/immunology Thymus Gland/immunology
Chemicals
Bacterial Proteins Lectins Concanavalin A Cortisone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kong A S
Morse S I
References (13)
13 references, click to expand
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    J Exp Med. 1977 Jan 1;145(1):163-74 PMID: 187716
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.145.1.151
Published
1977-01-01
Pages
151-62
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180587
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.145.1.151 PMC Full Text View journal details
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