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PMID: 18786415 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A specialized vascular niche for adult neural stem cells.

Cell stem cell ·Vol. 3 ·No. 3 ·2008-09-11 ·Pages 279-88

Tavazoie M, Van der Veken L, Silva-Vargas V, Louissaint M, Colonna L, Zaidi B, Garcia-Verdugo JM, Doetsch F

Abstract

Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult subventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.

MeSH Terms
Adult Stem Cells/cytology,physiology Animals Blood Vessels/cytology Brain/blood supply,cytology,physiology Cell Differentiation Cell Division Humans Lateral Ventricles/blood supply,cytology,physiology Mice Mice, Inbred Strains
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Tavazoie Masoud
Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York City, NY 10032 USA.
Van der Veken Lieven
Silva-Vargas Violeta
Louissaint Marjorie
Colonna Lucrezia
Zaidi Bushra
Garcia-Verdugo Jose Manuel
Doetsch Fiona
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Article Info
Journal
Cell stem cell
Abbr.
Cell Stem Cell
ISSN
1875-9777
DOI
10.1016/j.stem.2008.07.025
Published
2008-09-11
Pages
279-88
Language
English
Region
United States
NLM ID
101311472
PMCID
PMC6864413
Subset
IM
Grants
NINDS NIH HHS · R01 NS053884 · United States
NIGMS NIH HHS · T32 GM007367 · United States
NIGMS NIH HHS · T32 GM008224 · United States
Corrections
CommentIn
PMID: 18786409
External Links
PubMed source DOI: 10.1016/j.stem.2008.07.025 PMC Full Text View journal details
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