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PMID: 187916 Published · ppublish English Journal Article

XC cell fusion by murine leukemia viruses: fusion from without.

Medical microbiology and immunology ·Vol. 162 ·No. 3-4 ·1976-12-01 ·Pages 175-81

Ogura H

Abstract

Concentrated murine leukemia virus (MuLV) or MuLV producing cells induce XC cell fusion within an hour leading to syncytia formation. While MuLV inactivated by UV irradiation, beta-propiolactone or hydroxylamine treatment still caused cell fusion, Bromelin- or trypsin treated MuLV was no longer able to fuse XC cells. Though sonicated MuLV induced no XC cell fusion, it interfered with cell fusion as caused by untreated MuLV. XC cells infected by diluted MuLV of a titer lower than 1 X 10(5) PFU/ml formed no syncytia although they produced MuLV. The cell fusion mechanism is discussed.

MeSH Terms
Animals Bromelains/pharmacology Cell Fusion Cell Line Friend murine leukemia virus/drug effects,radiation effects Hydroxylamines/pharmacology Leukemia Virus, Murine/drug effects,radiation effects Propiolactone/pharmacology Sarcoma, Experimental Sonication Trypsin/pharmacology Ultraviolet Rays
Chemicals
Hydroxylamines Propiolactone Bromelains Trypsin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ogura H
References (19)
19 references, click to expand
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Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF02120995
Published
1976-12-01
Pages
175-81
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02120995 View journal details
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