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PMID: 18793650 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Architecture and flexibility of the yeast Ndc80 kinetochore complex.

Journal of molecular biology ·Vol. 383 ·No. 4 ·2008-11-21 ·Pages 894-903

Wang HW, Long S, Ciferri C, Westermann S, Drubin D, Barnes G, Nogales E

Abstract

Kinetochores mediate microtubule-chromosome attachment and ensure accurate segregation of sister chromatids. The highly conserved Ndc80 kinetochore complex makes direct contacts with the microtubule and is essential for spindle checkpoint signaling. It contains a long coiled-coil region with globular domains at each end involved in kinetochore localization and microtubule binding, respectively. We have directly visualized the architecture of the yeast Ndc80 complex and found a dramatic kink within the 560-A coiled-coil rod located about 160 A from the larger globular head. Comparison of our electron microscopy images to the structure of the human Ndc80 complex allowed us to position the kink proximal to the microtubule-binding end and to define the conformational range of the complex. The position of the kink coincides with a coiled-coil breaking region conserved across eukaryotes. We hypothesize that the kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore.

MeSH Terms
Amino Acid Sequence Chromosomal Proteins, Non-Histone/chemistry,metabolism Humans Kinetochores/chemistry,metabolism Macromolecular Substances/chemistry,metabolism Microscopy, Electron Microtubules/chemistry,metabolism Mitosis/physiology Models, Molecular Molecular Sequence Data Nuclear Proteins/chemistry,metabolism,ultrastructure Protein Conformation Saccharomyces cerevisiae/metabolism Saccharomyces cerevisiae Proteins/chemistry,metabolism,ultrastructure Sequence Alignment Stress, Mechanical
Chemicals
Chromosomal Proteins, Non-Histone Macromolecular Substances NDC80 protein, S cerevisiae Nuclear Proteins Saccharomyces cerevisiae Proteins Spc24 protein, S cerevisiae Spc25 protein, S cerevisiae
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Wang Hong-Wei
Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Long Sydney
Ciferri Claudio
Westermann Stefan
Drubin David
Barnes Georjana
Nogales Eva
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Article Info
Journal
Journal of molecular biology
Abbr.
J Mol Biol
ISSN
1089-8638
Published
2008-11-21
Epub
2008-00-05
Pages
894-903
Language
English
Region
England
NLM ID
2985088R
PMCID
PMC2640231
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · P01 GM051487-130017 · United States
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