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PMID: 1899910 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal alpha-actin promoter, and the immunoglobulin heavy-chain enhancer.

Molecular and cellular biology ·Vol. 11 ·No. 3 ·1991-03-00 ·Pages 1765-9

Riggs KJ, Merrell KT, Wilson G, Calame K

Abstract

Ubiquitously expressed transcription factors play an integral role in establishing and regulating patterns of gene transcription. Common factor 1 (CF1) is a ubiquitously expressed DNA-binding protein previously identified in our laboratory. We show here that CF1 recognizes sites in several diverse transcription elements, and we demonstrate the ability of the c-myc CF1 site to activate transcription of a basal promoter in both B cells and fibroblasts.

MeSH Terms
Actins/genetics Animals Base Sequence DNA-Binding Proteins/metabolism Enhancer Elements, Genetic Gene Expression Regulation Immunoglobulin Heavy Chains/genetics In Vitro Techniques Mice Molecular Sequence Data Oligonucleotides/chemistry Promoter Regions, Genetic Proto-Oncogene Proteins c-myc/genetics Transcription Factors/physiology Transcription, Genetic
Chemicals
Actins DNA-Binding Proteins Immunoglobulin Heavy Chains Oligonucleotides Proto-Oncogene Proteins c-myc Transcription Factors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Riggs K J
Department of Biological Chemistry, University of California Los Angeles 90024.
Merrell K T
Wilson G
Calame K
References (44)
44 references, click to expand
  1. Identification of a putative regulator of early T cell activation genes.
    Science. 1988 Jul 8;241(4862):202-5 PMID: 3260404
  2. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).
    EMBO J. 1988 Dec 20;7(13):4221-9 PMID: 3072196
  3. The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.
    Nature. 1989 Oct 19;341(6243):624-30 PMID: 2571937
  4. Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: extinction is dominant in a two enhancer system.
    Cell. 1989 Aug 11;58(3):441-8 PMID: 2547524
  5. The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.
    Cell. 1989 Aug 25;58(4):741-53 PMID: 2504497
  6. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
    Cell. 1989 Mar 10;56(5):777-83 PMID: 2493990
  7. Immunoglobulin gene transcription: molecular mechanisms.
    Trends Genet. 1989 Dec;5(12):395-9 PMID: 2696182
  8. Proteins binding to site C2 (muE3) in the immunoglobulin heavy-chain enhancer exist in multiple oligomeric forms.
    Mol Cell Biol. 1989 Feb;9(2):776-86 PMID: 2710123
  9. Five intermediate complexes in transcription initiation by RNA polymerase II.
    Cell. 1989 Feb 24;56(4):549-61 PMID: 2917366
  10. Negative control elements within and near the murine c-myc gene.
    Curr Top Microbiol Immunol. 1988;141:253-63 PMID: 3215054
  11. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.
    Science. 1988 Oct 21;242(4877):405-11 PMID: 3175662
  12. A plasmacytoma-specific factor binds the c-myc promoter region.
    Proc Natl Acad Sci U S A. 1987 Oct;84(20):7031-5 PMID: 3313385
  13. Regulation of inducible and tissue-specific gene expression.
    Science. 1987 Jun 5;236(4806):1237-45 PMID: 3296191
  14. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.
    Science. 1986 Oct 3;234(4772):47-52 PMID: 3529394
  15. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.
    Science. 1987 Oct 30;238(4827):688-92 PMID: 3499668
  16. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene.
    Cell. 1987 Dec 4;51(5):773-81 PMID: 3677172
  17. Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors.
    Science. 1985 Jan 18;227(4684):266-70 PMID: 3917575
  18. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.
    Science. 1985 Jan 11;227(4683):134-40 PMID: 3917574
  19. Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast.
    Genes Dev. 1990 Feb;4(2):299-312 PMID: 2159934
  20. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.
    Genes Dev. 1990 May;4(5):849-59 PMID: 2116362
  21. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
    Science. 1990 Jan 26;247(4941):467-70 PMID: 2105528
  22. A transcriptionally active form of TFIIIC is modified in poliovirus-infected HeLa cells.
    Mol Cell Biol. 1990 Oct;10(10):5106-13 PMID: 2204807
  23. A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.
    Mol Cell Biol. 1990 Feb;10(2):528-38 PMID: 2300053
  24. Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.
    J Mol Appl Genet. 1983;2(1):101-9 PMID: 6302193
  25. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.
    Genes Dev. 1990 Aug;4(8):1404-15 PMID: 2121606
  26. Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III.
    Science. 1988 Sep 2;241(4870):1210-3 PMID: 3413485
  27. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication.
    Cell. 1987 Jan 16;48(1):79-89 PMID: 3024847
  28. Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4352-6 PMID: 2525256
  29. Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.
    Mol Cell Biol. 1988 Feb;8(2):988-92 PMID: 2832747
  30. A transcriptional repressor of c-myc.
    Nature. 1989 Jun 29;339(6227):718-21 PMID: 2662014
  31. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements.
    Nucleic Acids Res. 1987 Jul 10;15(13):5490 PMID: 3037497
  32. Human growth hormone as a reporter gene in regulation studies employing transient gene expression.
    Mol Cell Biol. 1986 Sep;6(9):3173-9 PMID: 3023965
  33. Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation.
    Cell. 1988 Feb 12;52(3):435-45 PMID: 2830987
  34. OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences.
    Genes Dev. 1988 Nov;2(11):1400-13 PMID: 2850260
  35. An RNA polymerase II transcription factor inactivated in poliovirus-infected cells copurifies with transcription factor TFIID.
    Mol Cell Biol. 1988 Aug;8(8):3175-82 PMID: 2850483
  36. A negative transcriptional control element located upstream of the murine c-myc gene.
    EMBO J. 1986 May;5(5):899-904 PMID: 3013622
  37. The complete sequence of the mouse skeletal alpha-actin gene reveals several conserved and inverted repeat sequences outside of the protein-coding region.
    Mol Cell Biol. 1986 Jan;6(1):15-25 PMID: 3023820
  38. Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA.
    Mol Cell Biol. 1986 Dec;6(12):4168-78 PMID: 3025641
  39. In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.
    Nucleic Acids Res. 1988 Apr 25;16(8):3239-53 PMID: 3131736
  40. Complex protein binding within the mouse immunoglobulin heavy-chain enhancer.
    Mol Cell Biol. 1987 Dec;7(12):4194-203 PMID: 3125419
  41. O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation.
    Cell. 1988 Oct 7;55(1):125-33 PMID: 3139301
  42. Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation.
    Nucleic Acids Res. 1988 Jul 11;16(13):6085-96 PMID: 3135535
  43. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.
    Science. 1987 Jun 19;236(4808):1573-7 PMID: 3109035
  44. Molecular requirements for transcriptional initiation of the murine c-myc gene.
    Oncogene. 1989 May;4(5):549-58 PMID: 2471130
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.11.3.1765-1769.1991
Published
1991-03-00
Pages
1765-9
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369495
Subset
IM
Grants
NCI NIH HHS · R01CA38571 · United States
NIGMS NIH HHS · R01GM29361 · United States
External Links
PubMed source DOI: 10.1128/mcb.11.3.1765-1769.1991 PMC Full Text View journal details
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