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PMID: 19085030 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.

Clinical rheumatology ·Vol. 28 ·No. 4 ·2009-04-00 ·Pages 445-51

Ebina K, Fukuhara A, Ando W, Hirao M, Koga T, Oshima K, Matsuda M, Maeda K, Nakamura T, Ochi T, Shimomura I, Yoshikawa H, Hashimoto J

Abstract

Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7+/-6.7 microg/ml) than in the control (9.1+/-3.8 microg/ml) and mild RA groups (13.9+/-6.5 microg/ml) (control vs. mild RA group, P<0.001; mild RA vs. severe RA group, P<0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.

MeSH Terms
Adiponectin/blood Adult Aged Arthritis, Rheumatoid/blood,physiopathology Body Mass Index Case-Control Studies Disease Progression Dose-Response Relationship, Drug Female Humans Inflammation Joints/immunology,physiopathology Middle Aged Time Factors Treatment Outcome
Chemicals
Adiponectin
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Ebina Kosuke
Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Fukuhara Atsunori
Ando Wataru
Hirao Makoto
Koga Tadashi
Oshima Kazuya
Matsuda Morihiro
Maeda Kazuhisa
Nakamura Tadashi
Ochi Takahiro
Shimomura Iichiro
Yoshikawa Hideki
Hashimoto Jun
References (38)
38 references, click to expand
  1. The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis.
    Arthritis Rheum. 2001 Sep;44(9):2009-17 PMID: 11592361
  2. Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis.
    Mod Rheumatol. 2007;17(5):385-90 PMID: 17929130
  3. The potential of adiponectin in driving arthritis.
    J Immunol. 2006 Apr 1;176(7):4468-78 PMID: 16547285
  4. A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis.
    Ann Rheum Dis. 2008 Jun;67(6):769-74 PMID: 17965124
  5. Telmisartan but not candesartan affects adiponectin expression in vivo and in vitro.
    Hypertens Res. 2008 Apr;31(4):601-6 PMID: 18633170
  6. Adiponectin as a biomarker of the metabolic syndrome.
    Circ J. 2004 Nov;68(11):975-81 PMID: 15502375
  7. The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease.
    Arthritis Rheum. 1991 Jun;34(6):660-8 PMID: 2053913
  8. Increased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis.
    Cytokine. 2006 Sep;35(5-6):247-52 PMID: 17079158
  9. Therapeutic criteria in rheumatoid arthritis.
    J Am Med Assoc. 1949 Jun 25;140(8):659-62 PMID: 18150288
  10. Cartilage oligomeric matrix protein in serum and synovial fluid of rheumatoid arthritis: potential use as a marker for joint cartilage damage.
    Mod Rheumatol. 2004;14(5):356-60 PMID: 17143693
  11. Radiographic joint damage in early rheumatoid arthritis is highly dependent on body mass index.
    Arthritis Rheum. 2007 Nov;56(11):3575-82 PMID: 17968909
  12. Prediction of disease progression in early rheumatoid arthritis by ICTP, RF and CRP. A comparative 3-year follow-up study.
    Rheumatology (Oxford). 2000 Sep;39(9):1009-13 PMID: 10986307
  13. Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthritis. Longitudinal evaluation during methotrexate and azathioprine therapy.
    Arthritis Rheum. 1993 Aug;36(8):1070-9 PMID: 8393676
  14. Adiponectin differentially regulates cytokines in porcine macrophages.
    Biochem Biophys Res Commun. 2004 Apr 9;316(3):924-9 PMID: 15033490
  15. Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis.
    J Med Invest. 2006 Feb;53(1-2):87-94 PMID: 16538000
  16. The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese.
    Br J Rheumatol. 1997 Jun;36(6):630-6 PMID: 9236671
  17. Analysis of elevated serum interleukin-6 levels in rheumatoid arthritis: correlation with erythrocyte sedimentation rate or C-reactive protein.
    J Lab Clin Med. 1994 May;123(5):721-7 PMID: 8195678
  18. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
    Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83 PMID: 10092513
  19. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
    Diabetes. 2001 Sep;50(9):2094-9 PMID: 11522676
  20. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway.
    Exp Cell Res. 2005 Sep 10;309(1):99-109 PMID: 15963981
  21. Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers.
    Arthritis Rheum. 2007 Oct;56(10):3236-47 PMID: 17907159
  22. Predictors of radiographic joint damage in patients with early rheumatoid arthritis.
    Ann Rheum Dis. 2001 Oct;60(10):924-7 PMID: 11557647
  23. Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis.
    Clin Rheumatol. 2008 Jun;27(6):795-7 PMID: 18305977
  24. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.
    Ann Rheum Dis. 2006 Sep;65(9):1198-201 PMID: 16414972
  25. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.
    Biochem Biophys Res Commun. 2002 Jan 25;290(3):1084-9 PMID: 11798186
  26. Osteoclastogenesis in iliac bone marrow of patients with rheumatoid arthritis.
    J Rheumatol. 1997 Sep;24(9):1690-6 PMID: 9292789
  27. Adiponectin and inflammation: consensus and controversy.
    J Allergy Clin Immunol. 2008 Feb;121(2):326-30 PMID: 18061654
  28. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis.
    J Biol Chem. 2002 Oct 4;277(40):37487-91 PMID: 12138120
  29. Induction of hyperadiponectinemia following long-term treatment of patients with rheumatoid arthritis with infliximab (IFX), an anti-TNF-alpha antibody.
    Endocr J. 2008 Mar;55(1):213-6 PMID: 18270431
  30. Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis.
    Arthritis Rheum. 1992 Jan;35(1):26-34 PMID: 1731813
  31. Serum C1q levels as a prognostic guide to articular erosions in patients with rheumatoid arthritis.
    Arthritis Rheum. 1984 Aug;27(8):883-7 PMID: 6331829
  32. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
    Arthritis Rheum. 1988 Mar;31(3):315-24 PMID: 3358796
  33. Knee and/or hip joint destruction in rheumatoid arthritis is associated with HLA-DRB1*0405 in Japanese patients.
    Clin Rheumatol. 1998;17(6):485-8 PMID: 9890676
  34. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast.
    Biochem Biophys Res Commun. 2005 Jun 3;331(2):520-6 PMID: 15850790
  35. Cross-sectional and longitudinal study of osteoporosis in patients with rheumatoid arthritis.
    Clin Rheumatol. 2002 May;21(2):150-8 PMID: 12086167
  36. Comparison of Disease Activity Score (DAS)28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values.
    Ann Rheum Dis. 2007 Mar;66(3):407-9 PMID: 16926186
  37. C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes.
    J Endocrinol. 2007 Aug;194(2):275-81 PMID: 17641277
  38. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
    Nat Med. 2002 Jul;8(7):731-7 PMID: 12068289
Article Info
Journal
Clinical rheumatology
Abbr.
Clin Rheumatol
ISSN
1434-9949
DOI
10.1007/s10067-008-1074-y
Published
2009-04-00
Epub
2008-00-16
Pages
445-51
Language
English
Region
Germany
NLM ID
8211469
Subset
IM
External Links
PubMed source DOI: 10.1007/s10067-008-1074-y View journal details
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