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PMID: 191832 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Feline oncornavirus-associated cell-membrane antigen (FOCMA): distinction between FOCMA and the major virion glycoprotein.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 3 ·1977-03-00 ·Pages 1219-23

Stephenson JR, Essex M, Hino S, Hardy WD, Aaronson SA

Abstract

The humoral antibody response of feline leukemia virus (FeLV)-exposed cats to the feline oncornavirus-associated tumor cell-membrane antigen (FOCMA) is directly correlated with immunosurveillance against tumor development under natural conditions. By means of membrane immunofluorescence and radioimmunoprecipitation, the antibody response to FOCMA was found to be independent of the antibody response to the major envelope and core proteins of FeLV, gp70 and p30. This was especially true for healthy viremic cats, where antigenemia with circulating FeLV gp70 and p30 apparently binds any free antibody to these proteins, but high levels of FOCMA antibody are often concurrently present. Exhaustive in vitro absorption of highly immune nonviremic serum with gp70 and p30 also failed to remove FOCMA antibody activity. These results indicate that FOCMA is not one of these major FeLV structural proteins.

MeSH Terms
Animals Antibodies, Neoplasm/analysis Antibodies, Viral/analysis Antibody Formation Antibody Specificity Antigens, Neoplasm/analysis Antigens, Viral/analysis Cat Diseases/immunology Cats Cell Membrane/immunology Kinetics Leukemia/veterinary Leukemia Virus, Feline/immunology Viral Proteins/analysis,immunology
Chemicals
Antibodies, Neoplasm Antibodies, Viral Antigens, Neoplasm Antigens, Viral Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Stephenson J R
Essex M
Hino S
Hardy W D
Aaronson S A
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.3.1219
Published
1977-03-00
Pages
1219-23
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430654
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.3.1219 PMC Full Text View journal details
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