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PMID: 19217421 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Transcriptional control of endothelial cell development.

Developmental cell ·Vol. 16 ·No. 2 ·2009-02-00 ·Pages 180-95

De Val S, Black BL

Abstract

The transcription factors that regulate endothelial cell development have been a focus of active research for several years, and many players in the endothelial transcriptional program have been identified. This review discusses the function of several major regulators of endothelial transcription, including members of the Sox, Ets, Forkhead, GATA, and Kruppel-like families. This review also highlights recent developments aimed at unraveling the combinatorial mechanisms and transcription factor interactions that regulate endothelial cell specification and differentiation during vasculogenesis and angiogenesis.

MeSH Terms
Animals Cell Differentiation Cell Proliferation Endothelial Cells/metabolism Endothelium, Vascular/metabolism Hematopoietic Stem Cells/metabolism Humans Mesoderm/metabolism Mice Models, Biological Neovascularization, Pathologic Stem Cells/metabolism Transcription Factors/metabolism Transcription, Genetic Zebrafish
Chemicals
Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
De Val Sarah
Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, 94158, USA.
Black Brian L
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Article Info
Journal
Developmental cell
Abbr.
Dev Cell
ISSN
1878-1551
DOI
10.1016/j.devcel.2009.01.014
Published
2009-02-00
Pages
180-95
Language
English
Region
United States
NLM ID
101120028
PMCID
PMC2728550
Subset
IM
Grants
NHLBI NIH HHS · P01 HL089707 · United States
NHLBI NIH HHS · P01 HL089707-01A1 · United States
NIAMS NIH HHS · R01 AR052130 · United States
NHLBI NIH HHS · R01 HL064658-08 · United States
NHLBI NIH HHS · R01 HL064658 · United States
NIAMS NIH HHS · R01 AR052130-04 · United States
External Links
PubMed source DOI: 10.1016/j.devcel.2009.01.014 PMC Full Text View journal details
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