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PMID: 19231593 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Biology of the eosinophil.

Advances in immunology ·Vol. 101 ·2009-00-00 ·Pages 81-121

Blanchard C, Rothenberg ME

Abstract

In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the eosinophil, by placing it in the context of innate and adaptive immune responses. Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional interactions with dendritic cells and T cells, as well as their large panel of secreted cytokines and soluble mediators. The mechanisms and consequences of eosinophil responses in experimental inflammatory models and human diseases are discussed.

MeSH Terms
Animals Antigen Presentation/immunology Bacterial Infections/immunology,metabolism Cell Adhesion Molecules/immunology,metabolism Cytokines/immunology,metabolism Eosinophil Cationic Protein/immunology,metabolism Eosinophil Major Basic Protein/immunology,metabolism Eosinophil-Derived Neurotoxin/immunology,metabolism Eosinophils/immunology,physiology Humans Hypersensitivity/immunology,metabolism Integrins/immunology,metabolism Lymphocyte Function-Associated Antigen-1/immunology,metabolism Macrophage-1 Antigen/immunology,metabolism Mast Cells/immunology,metabolism Peroxidase/immunology,metabolism
Chemicals
Cell Adhesion Molecules Cytokines Integrins Lymphocyte Function-Associated Antigen-1 Macrophage-1 Antigen integrin alpha4beta7 Peroxidase Eosinophil-Derived Neurotoxin Eosinophil Cationic Protein Eosinophil Major Basic Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Blanchard Carine
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
Rothenberg Marc E
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Article Info
Journal
Advances in immunology
Abbr.
Adv Immunol
ISSN
0065-2776
DOI
10.1016/S0065-2776(08)01003-1
Published
2009-00-00
Pages
81-121
Language
English
Region
United States
NLM ID
0370425
PMCID
PMC4109275
Subset
IM
Grants
NIDDK NIH HHS · DK076893 · United States
NIAID NIH HHS · AI070235 · United States
Intramural NIH HHS · Z01 NR000014 · United States
NIAID NIH HHS · R37 AI045898 · United States
NIAID NIH HHS · AI45898 · United States
NIDDK NIH HHS · P30 DK0789392 · United States
NIAID NIH HHS · R01 AI045898 · United States
NIAID NIH HHS · U19 AI070235 · United States
NIDDK NIH HHS · R01 DK076893 · United States
NIAID NIH HHS · AI079874-01 · United States
NIAID NIH HHS · R21 AI079874 · United States
External Links
PubMed source DOI: 10.1016/S0065-2776(08)01003-1 PMC Full Text View journal details
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