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PMID: 2826636 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

The Journal of experimental medicine ·Vol. 167 ·No. 1 ·1988-01-01 ·Pages 219-24

Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA

Abstract

Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.

MeSH Terms
Eosinophils/drug effects,physiology,ultrastructure Humans Interleukin-5 Interleukins/pharmacology Neutrophils/drug effects Recombinant Proteins/pharmacology Superoxides/biosynthesis
Chemicals
Interleukin-5 Interleukins Recombinant Proteins Superoxides
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lopez A F
Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.
Sanderson C J
Gamble J R
Campbell H D
Young I G
Vadas M A
References (20)
20 references, click to expand
  1. A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni.
    J Immunol. 1979 Apr;122(4):1228-36 PMID: 448088
  2. Large cell carcinoma of the lung associated with marked eosinophilia. A case report.
    Cancer. 1984 Nov 15;54(10):2313-7 PMID: 6091864
  3. Enhanced helminthotoxic capacity of eosinophils from patients with eosinophilia.
    N Engl J Med. 1980 Nov 13;303(20):1147-52 PMID: 7421931
  4. The association of eosinophilia with lymphoblastic leukaemia or lymphoma: a study of seven patients.
    Br J Haematol. 1980 Aug;45(4):523-34 PMID: 6932954
  5. Comparison of human eosinophils from normals and patients with eosinophilia.
    J Clin Invest. 1980 Dec;66(6):1265-73 PMID: 7440715
  6. Activation of antibody-dependent cell-mediated cytotoxicity of human neutrophils and eosinophils by separate colony-stimulating factors.
    J Immunol. 1983 Feb;130(2):795-9 PMID: 6600255
  7. The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.
    J Cell Biol. 1985 Sep;101(3):1078-85 PMID: 4040915
  8. Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor.
    Blood. 1986 Jan;67(1):37-45 PMID: 3484428
  9. Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.
    Proc Natl Acad Sci U S A. 1986 Feb;83(4):1055-9 PMID: 3456562
  10. The pathogenesis of eosinophilic endomyocardial disease in patients with carcinomas of the lung.
    Heart Vessels. 1985 Aug;1(3):162-9 PMID: 3831022
  11. Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.
    J Exp Med. 1986 May 1;163(5):1085-99 PMID: 3486243
  12. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.
    J Clin Invest. 1986 Nov;78(5):1220-8 PMID: 3021817
  13. Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.
    J Immunol. 1986 Nov 15;137(10):3290-4 PMID: 3095427
  14. Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue.
    Nucleic Acids Res. 1986 Nov 25;14(22):9149-58 PMID: 3024129
  15. Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.
    Proc Natl Acad Sci U S A. 1987 May;84(9):2761-5 PMID: 3495002
  16. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).
    Proc Natl Acad Sci U S A. 1987 Oct;84(19):6629-33 PMID: 3498940
  17. Studies on blood eosinophils. I. Patients with a transient eosinophilia.
    Clin Exp Immunol. 1976 Jun;24(3):415-22 PMID: 939048
  18. Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes.
    Nature. 1977 Jul 28;268(5618):340-1 PMID: 329145
  19. Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants. Discrete responses correlated with chemotactic and secretory functions.
    J Clin Invest. 1984 May;73(5):1408-17 PMID: 6715544
  20. Unique characteristics of superoxide production by human eosinophils in eosinophilic states.
    Inflammation. 1979 Jul;3(3):261-72 PMID: 225266
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.167.1.219
Published
1988-01-01
Pages
219-24
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188822
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.167.1.219 PMC Full Text View journal details
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