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PMID: 19459931 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression.

The FEBS journal ·Vol. 276 ·No. 10 ·2009-05-00 ·Pages 2669-85

Zheng B, Han M, Bernier M, Wen JK

Abstract

Nuclear actin is involved in the transcription of all three RNA polymerases, in chromatin remodeling and in the formation of heterogeneous nuclear ribonucleoprotein complexes, as well as in recruitment of the histone modifier to the active gene. In addition, actin-binding proteins (ABPs) control actin nucleation, bundling, filament capping, fragmentation and monomer availability in the cytoplasm. In recent years, more and more attention has focused on the role of actin and ABPs in the modulation of the subcellular localization of transcriptional regulators. This review focuses on recent developments in the study of transcription and transcriptional regulation by nuclear actin, and the regulation of muscle-specific gene expression, nuclear receptor and transcription complexes by ABPs. Among the ABPs, striated muscle activator of Rho signaling and actin-binding LIM protein regulate actin dynamics and serum response factor-dependent muscle-specific gene expression. Functionally and structurally unrelated cytoplasmic ABPs interact cooperatively with nuclear receptor and regulate its transactivation. Furthermore, ABPs also participate in the formation of transcription complexes.

MeSH Terms
Actins/physiology Cell Nucleus/metabolism Gene Expression Regulation/physiology Microfilament Proteins/physiology Muscles/metabolism Transcription, Genetic/physiology
Chemicals
Actins Microfilament Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zheng Bin
Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China.
Han Mei
Bernier Michel
Wen Jin-kun
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Article Info
Journal
The FEBS journal
Abbr.
FEBS J
ISSN
1742-4658
DOI
10.1111/j.1742-4658.2009.06986.x
Published
2009-05-00
Pages
2669-85
Language
English
Region
England
NLM ID
101229646
PMCID
PMC2978034
Subset
IM
Grants
Intramural NIH HHS · Z01 AG000892-06 · United States
External Links
PubMed source DOI: 10.1111/j.1742-4658.2009.06986.x PMC Full Text View journal details
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