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PMID: 19490891 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The tortoise and the hair: slow-cycling cells in the stem cell race.

Cell ·Vol. 137 ·No. 5 ·2009-05-29 ·Pages 811-9

Fuchs E

Abstract

Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues.

MeSH Terms
Adult Stem Cells/cytology Animals Cell Cycle Cell Proliferation Hair Follicle/cytology Hematopoietic Stem Cells/cytology Humans Intestine, Small/cytology Organ Specificity
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Fuchs Elaine
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA. [email protected]
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2009.05.002
Email
[email protected]
Published
2009-05-29
Pages
811-9
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2716122
Subset
IM
Grants
NIAMS NIH HHS · R01 AR050452 · United States
NIAMS NIH HHS · R01 AR050452-04 · United States
NIAMS NIH HHS · R01 AR050452-05 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2009.05.002 PMC Full Text View journal details
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