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PMID: 19575639 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Membrane traffic within the Golgi apparatus.

Annual review of cell and developmental biology ·Vol. 25 ·2009-00-00 ·Pages 113-32

Glick BS, Nakano A

Abstract

Newly synthesized secretory cargo molecules pass through the Golgi apparatus while resident Golgi proteins remain in the organelle. However, the pathways of membrane traffic within the Golgi are still uncertain. Most of the available data can be accommodated by the cisternal maturation model, which postulates that Golgi cisternae form de novo, carry secretory cargoes forward and ultimately disappear. The entry face of the Golgi receives material that has been exported from transitional endoplasmic reticulum sites, and the exit face of the Golgi is intimately connected with endocytic compartments. These conserved features are enhanced by cell-type-specific elaborations such as tubular connections between mammalian Golgi cisternae. Key mechanistic questions remain about the formation and maturation of Golgi cisternae, the recycling of resident Golgi proteins, the origins of Golgi compartmental identity, the establishment of Golgi architecture, and the roles of Golgi structural elements in membrane traffic.

MeSH Terms
Animals Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Intracellular Membranes/metabolism Protein Transport Secretory Pathway
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Glick Benjamin S
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA. [email protected]
Nakano Akihiko
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Article Info
Journal
Annual review of cell and developmental biology
Abbr.
Annu Rev Cell Dev Biol
ISSN
1530-8995
DOI
10.1146/annurev.cellbio.24.110707.175421
Email
[email protected]
Published
2009-00-00
Pages
113-32
Language
English
Region
United States
NLM ID
9600627
PMCID
PMC2877624
Subset
IM
Grants
NIGMS NIH HHS · R01 GM061156 · United States
NIGMS NIH HHS · R01 GM061156-10 · United States
NIGMS NIH HHS · GM-61156 · United States
External Links
PubMed source DOI: 10.1146/annurev.cellbio.24.110707.175421 PMC Full Text View journal details
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