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PMID: 19575670 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?

Annual review of cell and developmental biology ·Vol. 26 ·2010-00-00 ·Pages 59-87

Nachury MV, Seeley ES, Jin H

Abstract

The primary cilium organizes numerous signal transduction cascades, and an understanding of signaling receptor trafficking to cilia is now emerging. A defining feature of cilia is the periciliary diffusion barrier that separates the ciliary and plasma membranes. Although lateral transport through this barrier may take place, polarized exocytosis to the base of the cilium has been the prevailing model for delivering membrane proteins to cilia. Key players for this polarized exocytosis model include the GTPases Rab8 and Rab11, the exocyst, and possibly the intraflagellar tranport machinery. In turn, the sorting of membrane proteins to cilia critically relies on the recognition of ciliary targeting signals by sorting machines such as the BBSome coat complex or the GTPase Arf4. Finally, some proteins need to exit from cilia, and ubiquitination may regulate this step. The stage is now set to dissect the interplay between signaling and regulated trafficking to and from cilia.

MeSH Terms
Animals Cell Membrane Cilia/metabolism,ultrastructure Eukaryota/cytology,metabolism Exocytosis Humans Intracellular Membranes/metabolism Membrane Proteins/metabolism Photoreceptor Cells, Vertebrate/cytology,metabolism Protein Transport Signal Transduction
Chemicals
Membrane Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nachury Maxence V
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5345, USA. [email protected]
Seeley E Scott
Jin Hua
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Article Info
Journal
Annual review of cell and developmental biology
Abbr.
Annu Rev Cell Dev Biol
ISSN
1530-8995
DOI
10.1146/annurev.cellbio.042308.113337
Email
[email protected]
Published
2010-00-00
Pages
59-87
Language
English
Region
United States
NLM ID
9600627
PMCID
PMC2952038
Subset
IM
Grants
NIGMS NIH HHS · R01 GM089933 · United States
NIGMS NIH HHS · R01 GM089933-01 · United States
NIGMS NIH HHS · 1R01GM089933-01 · United States
External Links
PubMed source DOI: 10.1146/annurev.cellbio.042308.113337 PMC Full Text View journal details
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