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PMID: 19605682 Published · ppublish English Journal Article Comment

Interpreting spatial information and regulating mitosis in response to spindle orientation.

Genes & development ·Vol. 23 ·No. 14 ·2009-07-15 ·Pages 1613-8

Burke DJ

Abstract

The spindle position checkpoint (SPOC) is a regulatory mechanism that ensures accurate segregation of chromosomes in polarized cells during mitosis. In this issue of Genes & Development, Chan and Amon (pp. 1639-1649) identify a phosphoprotein phosphatase (Rts1-PP2A) as a new member of the checkpoint in budding yeast and define its role in interpreting spatial information during mitosis.

MeSH Terms
Genes, cdc/physiology Methyltransferases/metabolism Mitosis/genetics Nuclear Proteins/metabolism Protein Kinases/metabolism Protein Phosphatase 2/metabolism Protein Serine-Threonine Kinases Saccharomyces cerevisiae/enzymology,growth & development Saccharomyces cerevisiae Proteins/metabolism Spindle Apparatus/genetics,metabolism
Chemicals
Nuclear Proteins Saccharomyces cerevisiae Proteins Methyltransferases SPB1 protein, S cerevisiae Protein Kinases KIN4 kinase, S cerevisiae Protein Serine-Threonine Kinases Protein Phosphatase 2
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Burke Daniel J
Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA. [email protected]
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.1826409
Email
[email protected]
Published
2009-07-15
Pages
1613-8
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC4899958
Subset
IM
Corrections
CommentOn
PMID: 19605686
External Links
PubMed source DOI: 10.1101/gad.1826409 PMC Full Text View journal details
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